己酮可可碱联合硫辛酸对老年衰弱综合征病人躯体功能及生活质量的影响

Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome

目的分析己酮可可碱联合硫辛酸对老年衰弱综合征病人躯体功能及生活质量的影响。方法选取2020年2月至2022年2月我院收治的老年衰弱综合征病人120例,将所有病人按随机数表法分为单药组(n=60)和联合组(n=60),单药组采用硫辛酸治疗,联合组在单药组基础上联合己酮可可碱治疗。比较2组的疗效、干预前后的握力和步速以及不良反应发生率。结果干预后,联合组和单药组的Fried评分显著降低(P<0.05),握力、步速、Tinetti-POMA、ADL和SF-36量表评分均显著提高(P<0.05),且联合组改善效果较单药组更明显,差异有统计学意义(P<0.05)。2组病人治疗前后安全性指标均在临床正常值范围内,2组不良反应发生率差异无统计学意义(15.00%比11.67%,P>0.05)。结论己酮可可碱联合硫辛酸干预可有效改善老年衰弱综合征病人的躯体功能及生活质量,安全性较好。

Objective To analyze the impacts of pentoxifylline combined with lipoic acid on physical function and quality of life in the elderly patients with frailty syndrome.Methods A total of 120 elderly patients with frailty syndrome admitted into our hospital from February 2020 to February 2022 were enrolled in this study,and all patients were divided to the single-drug group(n=60)and the combination group(n=60)according to random number table method.The single-drug group was treated with lipoic acid,and the combination group was given lipoic acid combined with pentoxifylline.The frailty was assessed by the Clinical Frailty Scale(Fried).The physical function was evaluated by Tinetti-Balance and Gait Scale(Tinetti-POMA)and the activities of daily living(ADL)scale,and the quality of life was assessed by MOS 36-Item Short Form Health Survey(SF-36).The efficacy,grip strength and pace speed before and after the intervention,and the incidence rate of adverse effects were observed and compared between the two groups.Results After the intervention,the Fried score was significantly decreased,and the grip strength,pace speed,scores of Tinetti-POMA,ADL scale and SF-36 were significantly increased in the two group,especially in the combination group(P<0.05).The safety indexes before and after treatment were all within the range of clinical normal values in the two groups,and there was no statistical difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusions Pentoxifylline combined with lipoic acid can effectively and safely improve the physical function and quality of life of the elderly patients with frailty syndrome.