早期子宫内膜癌患者腹腔镜术后口服甲羟孕酮的疗效及其对血清YKL-40、CA-125水平的影响

Effect of Oral Medroxyprogesterone on Patients with Early Endometrial Cancer After Laparoscopic Surgery and Its Influences on Serum YKL-40 and CA-125 Levels

目的探讨腹腔镜术后口服甲羟孕酮治疗早期子宫内膜癌患者的效果及对血清甲壳质酶蛋白-40(YKL-40)、糖类抗原-125(CA-125)水平的影响。方法选取110例早期子宫内膜癌患者为研究对象,随机分为对照组(55例)和观察组(55例),其中行腹腔镜手术治疗为对照组,腹腔镜手术联合甲羟孕酮治疗为观察组。比较2组疗效、血清YKL-40及CA-125水平。结果观察组总有效率(90.91%)明显高于对照组(70.91%)(P<0.05);治疗后两组CD8^(+)、FIB水平相较于治疗前明显升高,且观察组较对照组升高明显;两组CD4^(+)、CD4^(+)/CD8^(+)、YKL-40、CA-125、IL-8、CRP、TNF-α、PT及ARTT水平相较于治疗前明显降低,且观察组较对照组降低明显。结论腹腔镜手术联合甲羟孕酮治疗早期子宫内膜癌可有效改善患者免疫功能及凝血功能、抑制炎症反应,降低YKL-40、CA-125水平、效果显著。

Objective To explore the impact of oral medroxyprogesterone in the treatment of early endometrial cancer after laparoscopic surgery and its influences on the levels of serum chitinase protein-40(YKL-40)and carbohydrate antigen-125(CA-125).Methods A total of 110 patients with early endometrial cancer were collected as the research objects,and were randomly grouped into the control group(55 cases)and the observation group(55 cases),the control group was treated with laparoscopy,and the observation group was treated with laparoscopy combined with medroxyprogesterone.The efficacy,serum YKL-40,and CA-125 levels of the 2 groups were compared.Results The total effective rate of the observation group(90.91%)was obviously higher than that of the control group(70.91%)(P<0.05);after treatment,the levels of CD8^(+)and FIB in both groups obviously increased compared to before treatment,and the observation group showed a obvious increase compared to the control group;the levels of CD4^(+),CD4^(+)/CD8^(+),YKL-40,CA-125,IL-8,CRP,TNF-α,PT,and ARTT in the two groups were obviously reduced compared to before treatment,and the observation group showed a obvious decrease compared to the control group.Conclusion Laparoscopic surgery combined with medroxyprogesterone in the treatment of early endometrial cancer can effectively improve the immune function and coagulation function,inhibit inflammatory reaction,and reduce the levels of YKL-40 and CA-125,the effect is obvious.