子宫内膜癌患者PLR及肌层浸润深度与其术后预后的关系分析

Analysis of the Relationship Between PLR and Myometrial Infiltration Depth and Postoperative Prognosis in Patients with Endometrial Cancer

目的探讨子宫内膜癌(EC)患者血小板/淋巴细胞比值(PLR)及肌层浸润深度与其腹腔镜术后预后的关系。方法选取收治的预行腹腔镜手术的EC患者66例为研究对象,术前1周检测肌层浸润深度及PLR,统计患者术后4周预后不良发生率;根据其术后是否发生预后不良将其分为良好组和不良组,单因素分析EC患者腹腔镜术后预后不良的影响因素,Logistic回归分析EC患者腹腔镜术后预后不良的独立危险因素,Pearson相关性分析肌层浸润深度、术前PLR与EC患者腹腔镜术后预后不良的相关性。结果66例EC患者腹腔镜术后4周,预后良好48例,预后不良18例,其预后不良发生率为27.27%;单因素分析结果显示,不良组年龄、肿瘤直径、肌肉浸润深度≥1/2占比及术前PLR均高于良好组(P<0.05);Logistic回归分析结果显示,高龄、肌层浸润深度≥1/2、术前PLR较高均为EC患者腹腔镜术后预后不良的独立危险因素(P<0.05);Pearson相关性分析结果显示,肌层浸润深度≥1/2、术前PLR均与EC患者腹腔镜术后预后不良呈正相关(P<0.05)。结论肌层浸润深度、术前PLR与EC患者腹腔镜术后预后不良有关,其中肌层浸润深度≥1/2、较高术前PLR可能会增加术后预后不良风险。

Objective To explore the relationship between the platelet/lymphocyte ratio(PLR)and the depth of myometrial infiltration in patients with endometrial carcinoma(EC)and their prognosis after laparoscopic surgery.Methods 66 patients with EC who underwent laparoscopic surgery were selected as the study subjects.The depth of myometrial invasion and PLR were measured 1 week before surgery,and the incidence of poor prognosis was statistically analyzed 4 weeks after surgery.They were divided into good group and bad group according to whether there was a poor prognosis after surgery.Univariated analysis of the factors influencing the poor prognosis of EC patients after laparoscopic surgery.Logistic regression analysis was used to analyze independent risk factors for poor prognosis in patients with EC after laparoscopic surgery.Pearson correlation analysis was used to analyze the correlation between the depth of myometrial invasion,preoperative PLR,and poor prognosis after laparoscopic surgery in patients with EC.Results Four weeks after laparoscopic surgery,48 of 66 patients with EC had a good prognosis,and 18 had a poor prognosis.The incidence of poor prognosis was 27.27%.The results of univariate analysis showed that the age,tumor diameter,muscle invasion depth≥1/2,and preoperative PLR of the poor group were higher than those of the good group(P<0.05).Logistic regression analysis showed that older age,muscle invasion depth≥1/2,and higher preoperative PLR were independent risk factors for poor prognosis in patients with EC after laparoscopic surgery(P<0.05).Pearson correlation analysis showed that the depth of myometrial invasion≥1/2 and preoperative PLR were positively correlated with the poor prognosis of EC patients after laparoscopic surgery(P<0.05).Conclusion The depth of myometrial infiltration and preoperative PLR are associated with poor postoperative prognosis in EC patients undergoing laparoscopic surgery.Among them,myometrial infiltration depth≥1/2 and higher preoperative PLR may increase the risk of poor postoperative prognosis.