食管癌患者术前PLT、白细胞数、NLR及PLR水平对预后的预测价值

Predictive Value of Preoperative PLT,White Blood Cell Count,NLR and PLR Levels for Prognosis of Patients with Esophageal Cancer

目的探究术前血小板(PLT)、白细胞数、中性粒细胞与淋巴细胞比值(NLR)及外周血细胞与淋巴细胞比值(PLR)水平预测食管癌预后的价值。方法选取100例食管癌患者,于食管癌根治术前检测患者PLT、白细胞数、NLR及PLR水平。对患者进行为期2年的随访,根据患者预后分为复发组(36例)和未复发组(64例)。比较不同预后患者上述指标水平。多因素COX回归分析影响食管癌预后的因素。绘制ROC曲线评估PLT、白细胞数、NLR及PLR对食管癌患者预后的预测价值。结果复发组PLT水平明显低于未复发组(P<0.05),白细胞数、PLR、NLR明显高于未复发组(P<0.05)。多因素COX分析显示,NLR、PLT、PLR及白细胞数均为影响食管癌预后的因素(P<0.05)。绘制ROC曲线评估PLT、白细胞数、PLR、NLR预测食管癌患者预后的价值显示,单独检测时,NLR敏感度最高,PLT特异度最高,联合检测时敏感度、特异度最高。结论术前白细胞数、PLR、NLR、PLT水平与食管癌患者预后有关,四者联合检测预测食管癌预后的价值更高。

Objective To investigate the value of preoperative platelet(PLT),white blood cell count,neutrophil-lymphocyte ratio(NLR)and peripheral blood cell to lymphocyte ratio(PLR)in predicting the prognosis of esophageal cancer.Methods A total of 100 patients with esophageal cancer were selected to detect PLT,white blood cell count,NLR and PLR levels were detected before radical resection of esophageal cancer.The patients were followed up for 2 years,and were divided into recurrence group(36 cases)and non-recurrence group(64 cases)according to their prognosis.The levels of the above indexes were compared in patients with different prognosis.The factors affecting the prognosis of esophageal cancer were analyzed by multivariate COX regression.The ROC curve was drawn to evaluate the predictive value of PLT,white blood cell count,NLR and PLR on the prognosis of esophageal cancer patients.Results The level of PLT in recurrent group was significantly lower than that in non-recurrent group(P<0.05),and the number of white blood cells,PLR and NLR were significantly higher than those in non-recurrent group(P<0.05).Multivariate COX analysis showed that NLR,PLT,PLR and white blood cell count were the prognostic factors of esophageal cancer(P<0.05).The ROC curve was drawn to evaluate the prognostic value of PLT,white blood cell count,PLR and NLR in patients with esophageal cancer.The results showed that the sensitivity and specificity of NLR and PLT are the highest when detected separately,and the sensitivity and specificity are the highest when detected jointly.Conclusion The preoperative white blood cell count,PLR,NLR,and PLT levels are related to the prognosis of esophageal cancer patients,the combined detection of the four is more valuable in predicting the prognosis of esophageal cancer.