细胞死亡在NAFLD发生发展中的研究进展

Research progress on role of cell death in development of NAFLD

非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病之一,由无炎症单纯脂肪变性发展为非酒精性脂肪性肝炎(NASH),甚至发展为肝硬化和肝癌。NAFLD发病机制复杂,其中细胞凋亡,坏死等死亡方式均参与了NAFLD的发生发展,各种细胞死亡方式之间既存在很多重叠和联系,又存在差异。本文总结了不同细胞死亡方式参与NAFLD发生发展的机制,为NAFLD的临床研究和诊治提供理论基础。

Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases worldwide,which develops from simple steatosis without inflammation to nonalcoholic steatohepatitis(NASH),and even liver cirrhosis and liver cancer.The pathogenesis of NAFLD is complex,among which cell death modes such as apoptosis and necrosis are involved in the occurrence and development of NAFLD.There are many overlaps and connections between various cell death modes,as well as differences.This article summarizes the mechanism of different cell death modes involved in the occurrence and development of NAFLD,and provides a theoretical basis for the clinical research,diagnosis and treatment of NAFLD.