银杏酮酯滴丸联合尼可地尔治疗老年冠心病患者的效果及对血小板活化状态的影响

Effect of ginkgo ketone ester dropping pills combined with nicorandil in the treatment of elderly patients with coronary heart disease and its influence on platelet activation status

目的探究银杏酮酯滴丸联合尼可地尔治疗老年冠心病患者的效果及对血小板活化状态的影响。方法选取2020年5月至2022年9月收治的126例老年冠心病患者为研究对象,按照随机数字表法将其分为对照组与观察组,每组63例。对照组给予尼可地尔治疗,观察组在对照组基础上联合银杏酮酯滴丸治疗。比较两组的临床疗效、血小板活化指标以及心功能指标。结果观察组的治疗总有效率为93.65%,显著高于对照组的79.37%,差异具有统计学意义(P<0.05)。治疗后,观察组的α颗粒膜糖蛋白140(GMP-140)、血小板活化因子(PAF)、血小板第4因子(PF4)水平及血小板聚集率(PAR)低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的左心室射血分数(LVEF)高于对照组,左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)小于对照组,差异具有统计学意义(P<0.05)。结论银杏酮酯滴丸联合尼可地尔治疗老年冠心病不仅能够提升临床效果,还能改善血小板活化状态,促进心功能恢复。

Objective To explore the effect of ginkgo ketone ester dropping pills combined with nicorandil in the treatment of elderly patients with coronary heart disease and its influence on platelet activation status.Methods A total of 126 elderly patients with coronary heart disease admitted from May 2020 to September 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 63 cases in each group.The control group was treated with nicorandil,and the observation group was treated with ginkgo ketone ester dropping pills on the basis of the control group.The clinical efficacy,platelet activation indexes and cardiac function indexes were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.65%,which was significantly higher than 79.37%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of granule membrane protein-140(GMP-140),platelet activating factor(PAF),platlet factor 4(PF4)and platelet aggregation rate(PAR)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group,and the left ventricular end-diastolic dimension(LVEDD)and left ventricular end-systolic dimension(LVESD)were smaller than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Ginkgo ketone ester dropping pills combined with nicorandil in the treatment of elderly patients with coronary heart disease can not only enhance the clinical effect,but also improve the platelet activation status and promote the recovery of cardiac function.