盐酸氨溴索灌洗联合经鼻高流量鼻导管湿化氧疗治疗急性呼吸衰竭的效果

Effect of ambroxol hydrochloride lavage combined with high-flow nasal cannula oxygen therapy in the treatment of acute respiratory failure

目的分析盐酸氨溴索灌洗联合经鼻高流量鼻导管湿化氧疗(HFNC)治疗急性呼吸衰竭(ARF)的效果。方法选取2019年3月至2021年3月我院收治的78例ARF患者为研究对象,按照治疗方案差异将其分为对照组和研究组,各39例。对照组接受HFNC,研究组在对照组基础上给予盐酸氨溴索灌洗治疗。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白B-1(HMGB-1)、肺表面活性蛋白-D(SP-D)、丙二醛(MDA)、过氧化脂质(LPO)水平低于对照组(P<0.05)。治疗后,研究组的呼吸频率(RR)、气道阻力(Raw)低于对照组,氧合指数(PaO_(2)/FiO_(2))、动脉血氧饱和度(SaO_(2))、每分钟最大通气量(MVV)、用力肺活量(FVC)高于对照组(P<0.05)。结论盐酸氨溴索灌洗联合HFNC可调节ARF患者的氧化应激指标水平,改善肺功能,临床效果较佳,具有较高的临床应用价值。

Objective To analyze the effect of ambroxol hydrochloride lavage combined with high-flow nasal cannula oxygen therapy(HFNC)in the treatment of acute respiratory failure(ARF).Methods A total of 78 patients with ARF admitted in our hospital from March 2019 to March 2021 were selected as the research objects.According to the difference of treatment plan,the patients were divided into control group and study group,with 39 cases in each group.The control group received HFNC,and the study group was treated with ambroxol hydrochloride lavage on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),high mobility group box-1 protein(HMGB-1),surfactant associated protein-D(SP-D),malondialdehyde(MDA)and lipid peroxide(LPO)in the study group were lower than those in the control group(P<0.05).After treatment,the respiratory rate(RR)and airway resistance(Raw)in the study group were lower than those in the control group,and the oxygenation index(PaO_(2)/FiO_(2)),blood oxygen saturation(SaO_(2)),maximum ventilation per minute(MVV)and forced vital capacity(FVC)were higher than those in the control group(P<0.05).Conclusion Ambroxol hydrochloride lavage combined with HFNC can regulate the levels of oxidative stress indicators in patients with ARF and improve lung function,has better clinical effect and higher clinical application value.