卡前列素氨丁三醇联合卡前列甲酯栓对二次剖宫产产后出血控制效果及不良反应的影响

Effects of carboprost tromethamine combined with carboprost methylate suppository on postpartum hemorrhage control and adverse reactions in secondary cesarean section

目的分析卡前列素氨丁三醇联合卡前列甲酯栓对二次剖宫产产后出血的控制效果。方法选取2022年1月至12月收治的96例二次剖宫产产妇为研究对象,根据入院先后顺序将其分为对照组(48例,卡前列甲酯栓治疗)和研究组(48例,卡前列素氨丁三醇联合卡前列甲酯栓治疗)。比较两组的治疗效果。结果研究组的产后2、24 h出血量及产后出血率低于对照组,恶露持续时间、住院时间短于对照组,子宫底下降速度快于对照组,差异具有统计学意义(P<0.05)。治疗后,研究组的纤维蛋白原(FIB)、D-二聚体(D-D)、B型利尿肽(BNP)及一氧化氮水平低于对照组,血清钙水平高于对照组,差异具有统计学意义(P<0.05)。研究组的泌乳启动时间短于对照组,产后1、2 d泌乳量评分高于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇联合卡前列甲酯栓有利于提高二次剖宫产产后出血控制效果,调节血清指标,还有助于改善产妇泌乳功能,安全性良好,具有更高的应用价值。

Objective To analyze the control effect of carboprost tromethamine combined with carboprost methylate suppository on postpartum hemorrhage after secondary cesarean section.Methods A total of 96 parturients after secondary cesarean section admitted from January to December 2022 were selected as the research objects.According to the order of admission,the parturients were divided into control group(48 cases,carboprost methylate suppository)and study group(48 cases,carboprost tromethamine combined with carboprost methylate suppository).The therapeutic effects of the two groups were compared.Results The amount of bleeding at 2 and 24 h after delivery and the rate of postpartum hemorrhage in the study group were lower than those in the control group,the duration of lochia and hospitalization time were shorter than those in the control group,the decline rate of uterine fundus was faster than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of fibrinogen(FIB),D-Dimer(D-D),B-type natriuretic peptide(BNP)and nitric oxide in the study group were lower than those in the control group,the serum calcium level was higher than that in the control group,and the differences were statistically significant(P<0.05).The starting time of lactation in the study group was shorter than that in the control group,the scores of lactation volume at 1 and 2 d after delivery were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Carboprost tromethamine combined with carboprost methylate suppository is beneficial to improve the control effect of postpartum hemorrhage after secondary cesarean section,regulate serum indicators,and also help to improve maternal lactation function.It has good safety and higher application value.