定坤丹联合来曲唑、低剂量尿促性腺激素治疗多囊卵巢综合征不孕的效果及对子宫内膜容受性、排卵情况的影响

Effect of Dingkundan combined with letrozole and low-dose urinary gonadotropin on infertility of polycystic ovary syndrome and its influences on endometrial receptivity and ovulation

目的探讨定坤丹联合来曲唑、低剂量尿促性腺激素治疗多囊卵巢综合征不孕的效果及对子宫内膜容受性、排卵情况的影响。方法择取2020年1月至2022年12月收治的80例多囊卵巢综合征不孕患者为研究对象,按照随机数字表法将其分为对照组与观察组,各40例。对照组采用来曲唑、低剂量尿促性腺激素治疗,观察组在对照组基础上加用定坤丹治疗。比较两组的临床疗效、子宫内膜容受性及排卵改善情况。结果观察组的治疗总有效率为95.00%,高于对照组的75.00%,差异具有统计学意义(P<0.05)。治疗后,观察组的子宫内膜厚度大于对照组,子宫动脉阻力指数(RI)、搏动指数(PI)低于对照组,子宫动脉血流指数(FI)高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的卵泡数目、优势卵泡数多于对照组,卵泡成熟时间短于对照组,差异具有统计学意义(P<0.05)。结论定坤丹联合来曲唑、低剂量尿促性腺激素能够提升多囊卵巢综合征不孕的治疗效果,提高子宫内膜容受性,改善排卵情况,值得推广。

Objective To investigate the effect of Dingkundan combined with letrozole and low-dose urinary gonadotropin on infertility of polycystic ovary syndrome and its influences on endometrial receptivity and ovulation.Methods A total of 80 infertile patients with polycystic ovary syndrome admitted from January 2020 to December 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 40 cases in each group.The control group was treated with letrozole and low-dose urinary gonadotropin,and the observation group was treated with Dingkundan on the basis of the control group.The clinical efficacy,endometrial receptivity and ovulation improvement were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the endometrial thickness of the observation group was greater than that of the control group,the uterine artery resist index(RI)and pulsatility index(PI)were lower than those of the control group,and the uterine artery blood flow index(FI)was higher than that of the control group,and the differences were statistically significant(P<0.05).After treatment,the number of follicles and the number of dominant follicles in the observation group were more than those in the control group,and the follicular maturation time was shorter than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Dingkundan combined with letrozole and low-dose urinary gonadotropin can improve the therapeutic effect of polycystic ovary syndrome infertility,improve endometrial receptivity and ameliorate ovulation,which is worthy of promotion.