恩他卡朋双多巴片联合美多芭治疗老年帕金森病的效果分析

Effect analysis of entacapone levodopa and carbidopa tablets combined with madopar in treating elderly patients with Parkinson’s disease

目的分析恩他卡朋双多巴片联合美多芭治疗老年帕金森病(PD)的效果。方法选取2020-03—2023-03聊城市第二人民医院收治的PD老年患者154例,随机分为对照组(服用美多芭,77例)和研究组(服用恩他卡朋双多巴片联合美多芭,77例),比较2组患者的临床疗效、统一帕金森病评分量表(UPDRS)评分、血药浓度、氧化应激指标及不良反应。结果治疗后研究组总有效率92.21%,高于对照组的79.22%(χ^(2)=5.303,P=0.021)。治疗后2组患者的UPDRSⅠ~Ⅳ评分均下降,与同组治疗前比较有统计学差异(P<0.05),研究组低于对照组(P<0.05)。治疗后研究组患者的左旋多巴(LD)血药浓度为(2.59±0.51)mg/L,高于对照组的(2.16±0.45)mg/L(t=5.548,P<0.001)。治疗后对照组患者的氧化应激指标与同组治疗前比较无统计学差异(P>0.05),研究组患者的丙二醛降低,与同组治疗前比较有统计学差异(P<0.05),研究组低于对照组(P<0.05);研究组患者的超氧化物歧化酶、谷胱甘肽、谷胱甘肽过氧化物酶均升高,与同组治疗前比较有统计学差异(P<0.05),研究组高于对照组(P<0.05)。2组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论恩他卡朋双多巴片联合美多芭治疗老年PD疗效显著,能有效改善患者症状,提高血药浓度与机体抗氧化水平,安全性高。

Objective To observe the effect of entacapone levodopa and carbidopa tablets combined with madopar in the treatment of elderly patients with Parkinson’s disease(PD).Methods Totally 154 elderly patients with PD in Liaocheng Second People’s Hospital were selected from March 2020 to March 2023,and were randomly divided into control group(taken madopar,77 cases)and study group(taken entacapone levodopa and carbidopa tablets combined with madopar,77 cases).The clinical efficacy,unified Parkinson’s disease rating scale(UPDRS),blood drug concentration,oxidative stress indicators and adverse reactions were compared between both groups.Results After treatment,the total effective rate in study group was 92.21%,which was higher than 79.22%in control group(χ^(2)=5.303,P=0.021).The UPDRSⅠ-Ⅳscores in the two groups after treatment were reduced and significantly different from those before treatment(P<0.05),and the scores were lower in study group than those in control group(P<0.05).After treatment,the blood drug concentration of levodopa(LD)with(2.59±0.51)mg/L in study group was higher than(2.16±0.45)mg/L in control group(t=5.548,P<0.001).After treatment,the oxidative stress indicators in control group were not significantly different from those before treatment(P>0.05),and the malonaldehyde was declined in study group,with a significant difference compared to before treatment(P<0.05).The levels of superoxide dismutase,glutathione and glutathione peroxidase in study group were enhanced and significantly different compared to before treatment(P<0.05),and the levels in study group were higher than those in control group(P<0.05).There were no statistical differences in adverse reactions between the two groups(P>0.05).Conclusion Entacapone levodopa and carbidopa tablets combined with madopar has a significant efficacy on elderly PD,and can effectively improve the symptoms,and enhance the blood drug concentration and antioxidant level.