基于Nrf2/HO-1信号通路的中药有效成分缓解肝损伤研究进展

Research progress on alleviation of liver injury by active ingredients of traditional Chinese medicine based on Nrf 2/HO-1 signaling pathway

近年研究已证实,氧化应激是造成肝损伤的重要因素,研究发现核因子E2相关因子2(Nrf2)/血红素氧合酶-1(HO-1)可以通过调控氧化应激以缓解肝损伤。中药单体或中药复方可以通过调控该信号通路减少氧化应激、铁死亡、炎症和细胞焦亡的发生以缓解肝损伤。对中药中的黄酮类、多糖、酚酸、甾体类等有效成分通过Nrf2/HO-1信号通路在氧化应激与肝损伤之间的相互作用进行综述,对于寻求靶向Nrf2/HO-1信号通路发挥缓解肝损伤作用的中药提供依据,同时为中药治疗肝损伤作用机制的深入研究提供参考。

Oxidative stress is an important factor in liver injury,and studies have found that nuclear factor E2-related factor 2(Nrf 2)/heme oxygenase-1(HO-1)can alleviate liver injury by regulating oxidative stress.Traditional Chinese medicine(TCM)monomers or TCM compounds can alleviate liver injury by regulating this signaling pathway to reduce the occurrence of oxidative stress,ferroptosis,inflammation and pyroptosis.This article integrates the active ingredients such as flavonoids,polysaccharides,phenolic acids,and sterols in TCM to review the interaction between oxidative stress and liver injury through this signaling pathway,which provides strong evidence for seeking TCM that targets the Nrf 2/HO-1 signaling pathway to play a role in alleviating liver injury,provides effective ideas for further exploring the multi-faceted drug effects of effective substances in TCM,and provides a reference for the development of pharmacodynamics and in-depth research on the mechanism of action of TCM.