实炎方对湿热蕴肠型溃疡性结肠炎患者的临床疗效

Clinical effects of Shiyan Prescription on patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation

目的探讨实炎方对湿热蕴肠型溃疡性结肠炎患者的临床疗效。方法82例患者随机分为对照组和观察组,每组41例,对照组给予美沙拉嗪肠溶片,观察组在对照组基础上加用实炎方,疗程8周。检测临床疗效、中医证候评分、炎症因子(白细胞介素-6、白细胞介素-22、白细胞介素-33)、肠黏膜屏障功能指标(二胺氧化酶、D-乳酸、内毒素)、肠道菌群(大肠杆菌、肠球菌、双歧杆菌、乳酸杆菌)、GQOLI-74评分变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、血清炎症因子、肠黏膜屏障功能指标降低(P<0.05),GQOLI-74升高(P<0.05),肠球菌减少(P<0.05),双歧杆菌、乳酸杆菌增加(P<0.05),以观察组更明显(P<0.05)。结论实炎方可提高溃疡性结肠炎患者生活质量,临床疗效明显。

AIM To explore the clinical effects of Shiyan Prescription on patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation.METHODS Eighty-two patients were randomly assigned into control group(41 cases)for 8-week administration of Mesalazin Enteric-coated Tablets,and observation group(41 cases)for 8-week administration of both Shiyan Prescription and Enteric-coated Tablets.The changes in clinical effects,TCM syndrome scores,serum inflammatory factors(interleukin-6,interleukin-22,interleukin-33),intestinal mucosal barrier function indices(diamine oxidase,D-lactic acid,endotoxin),intestinal flora(Escherichia coli,Enterococcus,Bifidobacterium,Lactobacillus)and GQOLI-74 scores were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,serum inflammatory factors,intestinal mucosal barrier function indices(P<0.05),increased GQOLI-74 scores(P<0.05),reduced Enterococcus(P<0.05),and enhanced Bifidobacterium,Lactobacillus(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation,Shiyan Prescription can enhance life quality with obvious clinical effects.