虎杖对湿热证2型糖尿病患者的临床疗效

Clinical effects of Polygonum cuspidatum on patients with type 2 diabetes mellitus of Dampness-Heat Pattern

目的探讨虎杖对湿热证2型糖尿病患者的临床疗效。方法140例患者随机分为对照组和观察组,每组70例,对照组给予常规治疗,观察组在对照组基础上加用虎杖颗粒,疗程8周。检测体质量、BMI、血糖指标(FBG、2 h PG、HbA_(1C)、GA)、血脂指标(TC、TG、HDL-C、LDL-C、ApoA-I、ApoB、ApoA、ApoE、sdLDL-C)、肝功能指标(ALT、AST)、脂肪肝程度、TyG、HSI、中医证候评分和疗效变化。结果观察组中医证候总有效率高于对照组(P<0.01),脂肪肝程度更轻(P<0.01)。治疗后,观察组体质量、BMI、FBG、GA、TG、ApoE、TyG、HSI、ALT、中医证候评分降低(P<0.05,P<0.01),并且2 h PG、TyG、HSI、ALT、中医证候评分低于对照组(P<0.05,P<0.01)。结论虎杖可改善湿热证2型糖尿病患者糖脂代谢紊乱,值得临床推广应用。

AIM To explore the clinical effects of Polygonum cuspidatum Sieb.et Zucc.on patients with type 2 diabetes mellitus of Dampness-Heat Pattern.METHODS One hundred and forty patients were randomly assigned into control group(70 cases)for 8-week intervention of conventional treatment,and observation group(70 cases)for 8-week intervention of both P.cuspidatum granules and conventional treatment.The changes in body weight,BMI,blood glucose indices(FBG,2 h PG,HbA_(1C),GA),blood lipid indices(TC,TG,HDL-C,LDL-C,ApoA-I,ApoB,ApoA,ApoE,sdLDL-C),liver function indices(ALT,AST),fatty liver progression,TyG,HSI,TCM syndrome score and effects were detected.RESULTS The observation group demonstrated higher total effective rates of TCM syndromes than the control group(P<0.01),along with slighter fatty liver progression(P<0.01).After the treatment,the observation group displayed decreased body weight,BMI,FBG,GA,TG,ApoE,TyG,HSI,ALT and TCM syndrome score(P<0.05,P<0.01),and 2 h PG,TyG,HSI,ALT,TCM syndrome score were lower than those in the control group(P<0.05,P<0.01).CONCLUSION For the patients with type 2 diabetes mellitus of Dampness-Heat Pattern,P.cuspidatum can improve glucose and lipid metabolism disorders,which is worthy of clinical popularization and application.