失血性休克复苏液体的演进——低效价抗体O型全血正重新成为首选的应急通用桥接复苏液体

Evolution of resuscitation fluid for hemorrhagic shock——low titer group O whole blood is becoming preferred emergent universal bridging resuscitation fluid

血液复苏是严重失血患者的关键急救措施。血液复苏液体的选用,经历了从全血到晶体液/胶体液、晶体液联合红细胞、等比例血液成分的演进过程。近20年来,采用低效价抗体O型全血(low titer group O whole blood,LTOWB)作为血液复苏的首选应急通用桥接复苏液,已发展成为大趋势。我们对全血在严重失血患者的应用历史和现状做一介绍,并提出我国采用LTOWB作为首选应急通用血液的进一步论证和验证研究建议。

Timely and effective blood resuscitation is very important for patients with severe blood loss.The resuscitation fluids for hemorrhagic shock have evolved from whole blood to crystalloid/colloid solutions,crystalloid combined with red blood cells,to balanced blood components.In the past 20 years,it is a growing trend that low titer antibody group O whole blood(LTOWB)is used as the preferred universal bridging resuscitation fluid for emergent blood resuscitation.Herein we provide a review of the history and current status of whole blood for patients with severe bleeding and make a suggestion to launch a national implementation research program of LTOWB in China.