阿那白滞素在热性感染相关性癫痫综合征中的应用进展

Advances in the use of Anakinra in febrile infection-related epilepsy syndrome

热性感染相关性癫痫综合征(FIRES)主要表现为频繁的局灶性癫痫发作继发全面性癫痫发作及癫痫持续状态。多种抗癫痫发作药物治疗无效,急性期病死率高。幸存者遗留药物难治性癫痫及神经功能障碍。阿那白滞素是一种白细胞介素1受体拮抗剂,近来研究表明其在FIRES具有一定的疗效。现围绕阿那白滞素治疗FIRES的作用机制、疗效、安全性以及未来的挑战等方面进行分析,以期为阿那白滞素在FIRES中的应用提供依据。

Febrile infection-related epilepsy syndrome(FIRES)is primarily characterized by frequent focal epileptic seizures followed by generalized seizures and status epilepticus.Multiple anti-seizure drugs are ineffective in its treatment,and there′s a high mortality rate during the acute phase.Survivors often suffer from drug-resistant epilepsy and neurological dysfunctions.Anakinra is an interleukin-1 receptor antagonist.Recent studies have shown that it has potential therapeutic effects on FIRES.This article analyzes the mechanism,efficacy,safety,and future challenges of Anakinra in the treatment of FIRES,aiming to provide a basis for its application in FIRES.