口腔癌患者生存质量相关因素的系统评价

Systematic review of factors related to quality of life in patients with oral cancer:a systematic review

目的系统评价口腔癌患者生存质量的相关影响因素。方法系统检索中国知网、万方、维普、中国生物医学文献数据库、Pubmed、Medline、Web of Science、Embase、The Cochrane Library等中英文数据库中关于口腔癌患者生存质量的研究,检索时间限定为建库至2023年5月。纳入的所有研究由2名研究员独立筛选、提取资料并进行质量评级,主要采用定性分析的方法对研究结果进行总结。结果共纳入24篇文献,包括2717名患者。结果显示口腔癌患者生存质量的相关因素主要包含年龄、肿瘤TNM分期、是否放化疗和性别等22个因素,可归纳成个人因素、疾病相关因素和手术相关因素三方面。其中年龄、性别、肿瘤TNM分期、病理分期、颈清方式、婚姻状况、是否复发、是否吸烟和文化程度等因素的分析上,有超过5篇以上的文献报道,其结果比较一致。结论患者术后生存质量的相关影响因素众多。由于目前的临床研究多为横断面研究,且样本量有限,相关因素与生存质量之间的因果关系还需未来开展更多大样本的相关研究予以验证。

Objective This study aims to evaluate factors related to quality of life of patients with oral cancer.Methods CNKI,Wanfang,VIP,CBM,Pubmed,Medline,Web of Science,Embase,and The Cochrane Library were searched up to May 2023 for studies that evaluated the quality of life of patients with oral cancer.All the included studies were independently selected,extracted,and rated by two researchers,and results are summarized by qualitative analysis.Results Twenty-four articles on 2717 patients were included.Factors related to the quality of life of patients with oral cancer mainly included age,tumor TNM stage,radiochemotherapy,and gender,which could be summarized into three aspects:personal factors,disease-related factors,and surgical factors.More than five studies reported on the analysis of age,gender,tumor TNM stage,pathological stage,neck dissection method,marital status,recurrence,smoking,education level,etc.The results are relatively consistent.Conclusion The incidence of oral cancer increases,and many factors affected the quality of life.The included literature is a cross-sectional study,and the sample size is limited.The causal relationship between relevant factors and quality of life should be verified using large sample sizes.