比率低频振幅技术在延年九转法治疗慢性疲劳综合征伴焦虑抑郁中的应用价值

The application value of fractional amplitude of low frequency fluctuation in the treatment of chronic fatigue syndrome with anxiety depression by Prolong Life With Nine Turn method

目的比较延年九转法与认知行为治疗后,慢性疲劳综合征(chronic fatigue syndrome,CFS)伴焦虑与抑郁症状患者的大脑静息态下功能MRI(functional MRI,fMRI)比率低频振幅(fractional amplitude of low-frequency fluctuations,fALFF)的脑区差异改变情况。材料与方法将30例CFS患者随机分为延年九转法组和认知行为组,治疗12周后进行fMRI检测,采用Pearson相关分析探索fALFF变化与焦虑抑郁量表(Hospital Anxiety and Depression Scale,HADS)的线性相关性。结果与认知行为组相比,延年九转法组fALFF减弱的脑区有左侧梭状回、左侧枕上回、左侧角回;增强的脑区有右侧颞中回。焦虑症状分值与梭状回(r=0.525,P=0.044)和枕上回(r=0.559,P=0.030)的fALFF平均值呈正相关,抑郁症状分值与梭状回(r=0.542,P=0.037)的fALFF平均值呈正相关(P<0.05)。结论延年九转法可能通过梭状回、枕上回、角回、颞中回神经活动水平强弱客观反映CFS患者焦虑与抑郁症状。

Objective:To compare the regional differences in resting-state functional MRI(fMRI)fractional amplitude of low-frequency fluctuations(fALFF)in the brains of patients with chronic fatigue syndrome(CFS)accompanied by anxiety and depressive symptoms after treatment with the Prolong Life With Nine Turn(PLWNT)method versus cognitive-behavioral therapy(CBT).Materials and Methods:Thirty CFS patients were randomly assigned to either the PLWNT group or the cognitive behavioral therapy(CBT)group.FMRI was conducted after 12 weeks of treatment,and Pearson correlation analysis was employed to examine the linear relationship between changes in fALFF and the Hospital Anxiety and Depression Scale(HADS).Results:Compared to the control group,fALFF decreased in the left fusiform gyrus,left suproccipital gyrus,and left angular gyrus.The right medial temporal gyrus showed increased brain activity.Anxiety symptom scores positively correlated with fALFF values in the fusiform gyrus(r=0.525,P=0.044)and occipital gyrus(r=0.559,P=0.030),while depression symptom scores positively correlated with fALFF values in the fusiform gyrus(r=0.542,P=0.037)(P<0.05).Conclusions:The PLWNT may objectively reflect anxiety and depression symptoms in CFS patients through neural activity levels in the fusiform gyrus,occipital gyrus,angular gyrus,and middle temporal gyrus.