胶质瘤氨基酸PET/MR多模态影像的肿瘤体积及空间分布研究进展

Research progress of glioma volume and spatial distribution in amino acid PET/MR multimodal imaging

脑胶质瘤是成人最常见的原发恶性脑肿瘤,基于结构磁共振(magnetic resonance, MR)成像导航肿瘤手术切除是常规治疗方案。然而结构MR成像难以精准显示肿瘤的体积及空间分布,导致的肿瘤术后残留会缩短患者生存期。氨基酸正电子发射断层/磁共振(positron emission tomography/magnetic resonance, PET/MR)多模态影像显示的胶质瘤体积及空间分布存在重叠及差异,本文通过综述氨基酸PET与MR的结构、血流灌注及分子成像显示的胶质瘤体积及空间分布差异,探讨了多模态影像的肿瘤空间分布异质性,比较不同模态影像显示肿瘤空间分布的准确性,辅助临床制订PET/MR导航胶质瘤手术的最佳多模态影像组合,实现肿瘤最大化安全切除,提高患者预后生存质量,并且为未来进一步研究胶质瘤的分子生物学机制介导PET/MR影像空间分布表征提供思路。

Gliomas are the most common primary malignant brain tumors in adults,and resection of tumours based on structural magnetic resonance(MR)imaging is the conventional treatment.However,structural MR imaging is difficult to accurately demonstrate the volume and spatial distribution of the glioma,which leads to postoperative tumour residuals that may shorten the survival of patients.There are overlaps and differences in the volume and spatial distribution of gliomas shown by amino acid positron emission tomography/magnetic resonance(PET/MR)multimodal imaging.This paper reviewed the differences in the volume and spatial distribution of gliomas shown by amino acid PET and structure,perfusion,and molecular images of MR to explore the heterogeneity of tumour spatial distribution in multimodal images and compare the accuracy of spatial distribution of tumours in different modal images.It will assist developing the optimal multimodal image combination based on PET/MR for guiding glioma surgery,to maximize the safe resection of the tumour and improve the prognosis of glioma patients,as well as to provide insights for further research on spatial distribution characterization of PET/MR images mediated by the molecular biological mechanism of glioma.