小脑齿状核脑深部电刺激术对脑卒中后运动功能的改善作用

Prospects of dentate nucleus deep brain stimulation for poststroke motor recovery

脑卒中可以导致长期运动障碍,降低生活质量。尽管传统康复治疗取得的进展为患者带来曙光,仍有众多患者面临康复治疗效果有限的问题。神经调控技术即显示出突破性治疗潜力。本文旨在概述脑卒中后神经可塑性机制,探究小脑齿状核脑深部电刺激术改善脑卒中后运动功能的作用机制、总结研究进展,以为临床实践提供科学依据及新的治疗视角。

Stroke can lead to long-term motor disorders and reduced quality of life.Despite advances in conventional rehabilitation,many patients are still faced with limited efficacy of rehabilitation.Neuromodulation techniques have shown breakthrough therapeutic potential.The purpose of this article is to provide an overview of the mechanism of poststroke neuroplasticity,to explore the mechanism of dentate nucleus deep brain stimulation(DN-DBS)to improve poststroke motor function,and to summarize the progress of the study,in order to provide a scientific basis and a new therapeutic perspective for clinical practice of DN-DBS.