肝纯片对实验性肥胖高脂血症大鼠生理生化指标的影响

The Effect of Ganchun Tablets on Experimental Obese Hyperlipidemic Rats

目的:以实验性肥胖高脂血症大鼠为模型,探索肝纯片对实验性肥胖高血脂大鼠血脂四项和肝功能相关指标的影响。方法:通过对实验大鼠进行喂食高脂饲料8周后,建立肥胖高脂血症大鼠模型。再喂食含不同浓度的肝纯片,持续喂肝纯片8周后解剖实验大鼠并测定甘油三酯(TG)、胆固醇(TCH)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)以及肝功能指标、炎症因子、肝脏指数、Lee’s指数,对肝脏进行病理切片,表征肝纯片对肥胖高脂血症大鼠的影响情况和程度及肝脏的保护情况。结果:肝纯片各剂量组降低了血脂水平,以高剂量差异显著,但减肥效果尚未见显著差异。结论:结合相关指标及病理切片,比较肝纯片各剂量组、空白组与模型组,肝纯片能降低高脂血症大鼠血液中血脂水平,提示进食肝纯片有助于降低高脂血症的血脂指标,并改善由高脂血症导致的肝功能紊乱,值得进一开发利用。

Objective:This study aimed to explore the effects of ganchun tablets on blood lipid levels and liver function indicators in experimental obese hyperlipidemic rats using an experimental model of obesity and hyperlipidemia in rats.Methods:The experimental rats were fed a high-fat diet for 8 weeks to establish the model of obese hyperlipidemic rats.Then,the rats were fed ganchun tablets with different concentrations for 8 weeks,and the levels of triglycerides(TG),total cholesterol(TCH),high-density lipoprotein(HDL),low-density lipoprotein(LDL),liver function indicators,liver index,and Lee’s index were measured after dissecting the rats.Liver pathology sections were also examined to characterize the effects and degree of liver puree on obese hyperlipidemic rats and the protective effect on the liver.Results:Ganchun tablets at different doses reduced blood lipid levels,with a significant difference observed in the high-dose group,but there was no significant difference in weight loss effect.Conclusion:Combined with relevant indicators and pathological sections,comparing the different dose groups of liver puree,the blank group,and the model group,liver puree can reduce blood lipid levels in hyperlipidemic rats,suggesting that consuming liver puree may help lower blood lipid levels in hyperlipidemia and improve liver function disorders caused by hyperlipidemia,which is worth further development and utilization.