超声造影参数与早期卵巢癌患者腹腔镜术后淋巴结转移的相关性研究

Correlation Study between Ultrasonography Parameters and Lymph Node Metastasis after Laparoscopic Surgery in Patients with Early Ovarian Cancer

目的:探讨超声造影参数与早期卵巢癌患者腹腔镜术后淋巴结转移的相关性。方法:回顾性分析2021年3月—2022年10月新疆医科大学第七附属医院行腹腔镜手术治疗后1年内发生淋巴结转移的50例早期卵巢癌患者临床资料,将其设为淋巴结转移组,另选择同期接受腹腔镜手术治疗后1年内未发生淋巴结转移的50例早期卵巢癌患者作为非淋巴结转移组。收集两组患者的临床资料,并对比两组患者超声造影参数差异。分析早期卵巢癌患者超声造影参数与其术后淋巴结转移的相关性,采用ROC曲线分析超声造影定量参数对早期卵巢癌患者腹腔镜术后淋巴结转移的诊断效能。结果:与非淋巴结转移组患者基础强度和达峰时间对比,淋巴结转移组患者基础强度明显降低,达峰时间明显缩短,差异有统计学意义(P<0.05);两组患者灌注时间、增强强度、到达时间以及峰值强度等超声造影参数比较,差异无统计学意义(P>0.05)。Spearman相关性分析结果显示,基础强度和达峰时间等超声造影参数与早期卵巢癌患者腹腔镜术后1年内淋巴结转移呈负相关;ROC结果显示,基础强度和达峰时间单独及联合检测早期卵巢癌患者腹腔镜术后1年内淋巴结转移的AUC值分别为0.731、0.796和0.855。结论:基础强度和达峰时间与早期卵巢癌患者腹腔镜术后1年内淋巴结转移具有较高的相关性,且基础强度和达峰时间联合检测可提高对早期卵巢癌患者腹腔镜术后1年内淋巴结转移预测效能。

Objective:To investigate the correlation between ultrasonographic parameters and lymph node metastasis after laparoscopic surgery in patients with early-stage ovarian cancer.Method:The clinical data of 50 early ovarian cancer patients who developed lymph node metastasis within 1 year after laparoscopic surgical treatment in the Seventh Affiliated Hospital of Xinjiang Medical University from March 2021 to October 2022 were retrospectively analyzed,and they were set as the lymph node metastasis group,and 50 early ovarian cancer patients who did not develop lymph node metastasis within 1 year after receiving laparoscopic surgical treatment in the same period were selected as the non-lymph node metastasis group.The clinical data of the two groups of patients were collected,and the differences in ultrasonography parameters between the two groups were compared.The correlation between ultrasonography parameters and their postoperative lymph node metastasis in patients with early-stage ovarian cancer was analyzed,and the diagnostic efficacy of quantitative ultrasonography parameters on lymph node metastasis after laparoscopy in patients with early-stage ovarian cancer was analyzed by using ROC curve.Result:Compared with the basal intensity and peak time of patients in the non-lymph node metastasis group,the basal intensity of patients in the lymph node metastasis group was significantly lower and the peak time was significantly shorter,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the comparison of ultrasonographic parameters such as perfusion time,enhancement intensity,arrival time and peak intensity between the two groups(P>0.05).Spearman correlation analysis showed that ultrasonography parameters such as base intensity and time to peak were negatively correlated with lymph node metastasis within 1 year after laparoscopy in patients with early-stage ovarian cancer.The ROC results showed that the AUC values of base intensity and time to peak,alone and in combination,for detecting lymph node metastasis within 1 year after laparoscopy in patients with early-stage ovarian cancer were 0.731,0.796 and 0.855,respectively.Conclusion:Basal intensity and time to peak have high correlation with lymph node metastasis within 1 year after laparoscopic surgery in patients with early-stage ovarian cancer,and the combined detection of basal intensity and time to peak can improve the efficacy of predicting lymph node metastasis within 1 year after laparoscopic surgery in patients with early-stage ovarian cancer.