经支气管等动脉化疗栓塞对70岁以上非手术老年肺癌患者的效果

Effectiveness of Transbronchial Isoarterial Chemoembolization in Non-surgical Elderly Patients over 70 Years Old with Lung Cancer

目的:探讨经支气管等动脉化疗栓塞对70岁以上非手术老年肺癌患者的效果。方法:回顾性分析2021年11月—2023年6月海军安庆医院介入与血管外科收治的84例70岁以上非手术老年肺癌患者的临床资料,根据患者的治疗方式分为对照组40例和试验组44例。对照组患者接受静脉化疗,试验组患者接受经支气管等动脉化疗栓塞治疗。比较两组患者治疗效果、治疗前后肺功能、肿瘤因子水平及毒副反应发生情况。结果:试验组患者疾病控制率(DCR)高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组患者肺功能情况优于对照组,差异有统计学意义(P<0.05)。治疗后,试验组患者癌胚抗原(CEA)、糖类抗原125(CA125)及细胞角蛋白19的可溶性片段(CYFRA21-1)水平低于对照组,差异有统计学意义(P<0.05)。试验组患者毒副反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:经支气管等动脉化疗栓塞治疗70岁以上非手术老年肺癌的疗效优于静脉化疗,可使患者的肺功能得到有效改善,降低患者机体肿瘤因子水平,同时可减轻治疗产生的毒副反应。

Objective:To investigate the efficacy of transbronchial isoarterial chemoembolization in non-surgical elderly patients over 70 years old with lung cancer.Method:The clinical data of 84 non-surgical elderly lung cancer patients over 70 years old admitted to the Department of Interventional and Vascular Surgery of Naval Anqing Hospital from November 2021 to June 2023 were retrospectively analyzed,and the patients were divided into the control group and the experimental group according to their treatment,with 4 cases in each group.Patients in the control group received intravenous chemotherapy,and patients in the experimental group received transbronchial and other arterial chemoembolization treatment.The treatment effect,lung function,tumor factor level and the occurrence of toxic side effects before and after treatment were compared between the two groups.Result:Disease Control Rate(DCR)of patients in the test group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the lung function condition of patients in the test group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of carcinoembryonic antigen(CEA),glycan antigen 125(CA125)and soluble fragment of cytokeratin 19(CYFRA21-1)in the test group were lower than those in the control group,and the difference was statistically significant(P<0.05).The incidence of toxic side effects in patients in the test group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The efficacy of transbronchial and other arterial chemoembolization for the treatment of non-surgical elderly lung cancer over 70 years old is better than that of intravenous chemotherapy,which can effectively improve the lung function of the patients,reduce the level of tumor factor in the patients'organisms,and at the same time,can alleviate the toxic side-effects produced by the treatment.