羟考酮联合七氟烷在腹腔镜胃肠癌手术中的应用

Application of Oxycodone Combined with Sevoflurane in Laparoscopic Surgery for Gastrointestinal Cancer

目的:探讨羟考酮联合七氟烷在腹腔镜胃肠癌手术中的应用。方法:选择2022年8月—2023年8月福建省肿瘤医院收治的90例腹腔镜胃肠癌手术患者作为研究对象。根据麻醉用药不同将患者分为对照组和观察组,各45例。对照组使用七氟烷麻醉,观察组使用羟考酮联合七氟烷麻醉。对比两组复苏情况、疼痛情况、炎症细胞因子水平、不良反应。结果:观察组自主呼吸恢复时间、拔管时间、苏醒时间均早于对照组,术后躁动发生率低于对照组,差异有统计学意义(P<0.05)。观察组术后6 h、12 h、24 h视觉模拟评分法(visual analogue scales,VAS)评分均低于对照组,差异有统计学意义(P<0.05)。麻醉前,两组白细胞介素-2(interleukin-2,IL-2)、白细胞介素-10(interleukin-10,IL-10)、白细胞介素-13(interleukin-13,IL-13)、γ干扰素(interferon,INF-γ)水平比较,差异无统计学意义(P>0.05);术后,两组IL-2、IL-10、IL-13、INF-γ水平均高于麻醉前,观察组IL-2、INF-γ水平低于对照组,IL-10、IL-13水平高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:羟考酮联合七氟烷麻醉能缩短腹腔镜胃肠癌手术患者麻醉术后苏醒时间,减轻术后疼痛,调节炎症细胞因子水平,减少不良反应。

Objective:To explore the application of Oxycodone combined with Sevoflurane in laparoscopic surgery for gastrointestinal cancer.Method:A total of 90 patients who undergoing laparoscopic surgery for gastrointestinal cancer in Fujian Cancer Hospital from August 2022 to August 2023 were selected as the research objects,the patients were divided into the control group and the observation group according to the different anesthetic drugs,45 cases in each group.The control group was anesthetized with Sevoflurane,while the observation group was anesthetized with Oxycodone combined with Sevoflurane.The recovery,pain,levels of inflammatory cytokines,and adverse reactions between the two groups were compared.Result:The spontaneous respiratory recovery time,extubation time and recovery time in the observation group were earlier than those in the control group,and the incidence of postoperative agitation was lower than that in the control group,the differences were statistically significant(P<0.05).The visual analogue scales(VAS)scores at 6 h,12 h and 24 h after operation of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Before anesthesia,there were no significant differences in the levels of interleukin-2(IL-2),interleukin-10(IL-10),interleukin-13(IL-13)and interferon-γ(INF-γ)between two groups(P>0.05);after operation,the levels of IL-2,IL-10,IL-13 and INF-γin the two groups were higher than those before anesthesia,the levels of IL-2 and INF-γin the observation group were lower than those in the control group,and the levels of IL-10 and IL-13 were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Oxycodone combined with Sevoflurane anesthesia can shorten the recovery time after anesthesia in patients undergoing laparoscopic surgery for gastrointestinal cancer,reduce postoperative pain,regulate the levels of inflammatory cytokines,and reduce adverse reactions.