Ang-2、IL-6及IL-8对老年重症肺炎患者预后的预测价值

Predictive Value of Ang-2,IL-6 and IL-8 on Prognosis of Elderly Patients with Severe Pneumonia

目的:研究血管紧张素-2(Ang-2)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)对老年重症肺炎患者预后的预测价值。方法:选取2022年9月—2023年9月建瓯市立医院收治的95例老年重症肺炎患者。检测所有患者Ang-2、IL-6及IL-8水平。对所有患者进行分组。分析分组情况。比较两组Ang-2、IL-6及IL-8水平。分析老年重症肺炎患者预后影响因素。分析Ang-2、IL-6及IL-8预测老年重症肺炎患者预后的价值。结果:95例老年重症肺炎患者随访3个月后发现,27例病死,纳入预后不良组,68例存活,纳入预后良好组,预后不良发生率为28.42%(27/95)。预后不良组Ang-2、IL-6及IL-8水平均高于预后良好组,差异有统计学意义(P<0.05)。logistic回归分析结果显示,Ang-2、IL-6及IL-8均是老年重症肺炎患者预后的影响因素(P<0.05)。Ang-2、IL-6及IL-8对老年重症肺炎患者预后的预测价值的曲线下面积(AUC)分别为0.937、0.899、0.944,均有一定预测价值,联合三者的AUC更高,为0.992,其敏感度、特异度达到0.963、0.971。结论:检测血清Ang-2、IL-6及IL-8表达对老年重症肺炎患者预后结局具有一定的预测价值,且联合检测的预测价值更高。

Objective:To investigate the predictive value of angiotensin-2(Ang-2),interleukin-6(IL-6)and interleukin-8(IL-8)on prognosis of elderly patients with severe pneumonia.Method:A total of 95 elderly patients with severe pneumonia treated in Jian’ou Municipal Hospital from September 2022 to September 2023 were selected.The levels of Ang-2,IL-6 and IL-8 were detected in all patients.All patients were grouped.The grouping condition was analyzed.The levels of Ang-2,IL-6 and IL-8 were compared between the two groups.The prognostic influencing factors of senile patients with severe pneumonia was analyzed.The predictive value of Ang-2,IL-6 and IL-8 on prognosis in elderly patients with severe pneumonia was analyzed.Result:Among 95 elderly patients with severe pneumonia followed up for 3 months,27 died and were included in the poor prognosis group,68 survived and were included in the good prognosis group,and the incidence of poor prognosis was 28.42%(27/95).The levels of Ang-2,IL-6 and IL-8 in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P<0.05).logistic regression analysis showed that Ang-2,IL-6 and IL-8 were prognostic influencing factors in elderly patients with severe pneumonia(P<0.05).The area under curve(AUC)values of Ang-2,IL-6 and IL-8 in predicting prognosis of elderly patients with severe pneumonia were 0.937,0.899 and 0.944 respectively,all of which had certain predictive value.The AUC values of the combination of Ang-2,IL-6 and IL-8 were higher(0.992),and their sensitivity and specificity were 0.963 and 0.971.Conclusion:The detection of serum Ang-2,IL-6,and IL-8 expression has certain predictive value for the prognosis of elderly patients with severe pneumonia,and the combined detection has higher predictive value.