基于纤维芯层流体力学方法制备聚合物功能微球研究进展

Research Progress on Polymer Functional Microspheres Preparation Through Fiber Core Based Hydrodynamic Method

聚合物复合微球在医药、传感、光学、显示等领域,特别是在医药领域的临床诊断、病理成像和药物输送等方面具备重要应用价值。但是,聚合物复合微球的合成路线复杂、加工效率低下,常规工艺通常难以兼顾微球粒径单分散性、生产成本、产量等综合要求。近年来,纤维芯层流体力学方法依据纤维内发生的流体界面不稳定性(PRI)现象,可在微纳米尺度制备具有高度单分散性的聚合物微球,同时成本可控,适合批量生产。本文综述了流体界面不稳定性原理、纤维芯层PRI方法制备工艺、功能微球和结构微球的纤维芯层PRI方法制备等方面的最新进展,以及针对纤维芯层PRI方法的最新改进。

Polymer composite microspheres have important applications in the fields of medicine,sensing,optics and display,especially in clinical diagnosis,pathological imaging and drug delivery in the field of medicine.However,due to the complex synthesis route and low processing efficiency,conventional technologies are often difficult to take into account the good particle size dispersion,low production cost and high yield of microspheres.In recent years,based on Plateau-Rayleigh fluid interface instability(PRI)in fibers,laminar hydrodynamic methods can prepare highly monodisperse polymer microspheres at micro or nano scale with controllable cost and considerable yield.In this paper,the principle of fluid interface instability,the preparation process of fiber core layer PRI method,the preparation of functional microspheres and structural microspheres of fiber core layer PRI method and the improvement of fiber core layer PRI method are reviewed.