非酒精性脂肪性肝病肝纤维化程度与心脏左心室改变的关系

Relationship Between the Degree of Liver Fibrosis and Left Ventricular Changes in Non-alcoholic Fatty Liver Disease

目的探讨非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)肝纤维化程度与心脏左心室结构和功能的关系。方法收集2022年6月~2023年4月新疆医科大学第二附属医院收治的NAFLD患者411例,将NAFLD患者通过FIB-4无创肝纤维化评分系统进行分层,分为进展期纤维化组(n=138)和非进展期纤维化组(n=273),选择同期就诊的腹部超声检查正常的151例患者为对照组,分析NAFLD患者肝纤维化严重程度与心脏左心室结构和功能的关系。结果NAFLD患者肝纤维化是心脏舒张功能受限的危险因素(P<0.05),且肝纤维化程度越重,心脏舒张功能受限越重。结论NAFLD肝纤维化程度与心脏左心室舒张功能受限显著相关,与心脏左心室结构改变可能相关。

Objective To investigate the relationship between the degree of liver fibrosis in non-alcoholic fatty liver disease(NAFLD)and the left ventricular structure and function of the heart.Methods A total of 411 patients with NAFLD admitted to the Sec-ond Affiliated Hospital of Xinjiang Medical University from June 2022 to April 2023 were collected.NAFLD patients were stratified using the FIB-4 non-invasive liver fibrosis scoring system and divided into the progressive fibrosis group(n=138)and non-progressive fi-brosis group(n=273).A total of 151 patients with normal abdominal ultrasound examination during the same period were selected as the control group,the relationship between the severity of liver fibrosis in NAFLD patients and the left ventricular structure and function of the heart were analyzed.Results Liver fibrosis was a risk factor for cardiac diastolic function limitation in NAFLD patients(P<O.05),and the more severe the degree of liver fibrosis,the more severe the cardiac diastolic function limitation.Conclusion The degree of liver fi-brosis in NAFLD is significantly correlated with limited left ventricular diastolic function;it may be related to changes in the left ventricu-lar structure of the heart.