止喘灵口服液治疗儿童咳嗽变异性哮喘(风热袭肺证)的疗效观察

Clinical observation of Zhichuanling Oral Liquid in treatment of cough variant asthma in children(wind-heat attacking lung syndrome)

目的 探讨止喘灵口服液治疗儿童咳嗽变异性哮喘(风热袭肺证)的临床疗效。方法 选取2021年11月—2022年12月在南京中医药大学附属医院儿科门诊就诊的60例咳嗽变异性哮喘患儿,按随机数字表法将患儿分为对照组(33例)和治疗组(27例)。对照组2岁≤患儿年龄<5岁患儿温开水冲服孟鲁司特钠颗粒,4 mg/次,每晚1次;5岁≤患儿年龄<14岁患儿咀嚼后吞咽孟鲁司特钠咀嚼片,5 mg/次,每晚1次。治疗组口服止喘灵口服液,2岁≤患儿年龄<3岁,3 mL/次;3岁≤患儿年龄<9岁,6 mL/次;≥10岁者,10 mL/次,3次/d。两组均治疗2周。观察两组的临床疗效,比较两组主要症状评分、次要症状评分和中医证候总评分。结果 治疗后,治疗组患者控显率是63.0%,显著高于对照组的21.2%(P<0.05);治疗组总有效率是96.3%,对照组是90.9%,两组总有效率比较差异无统计学意义。治疗后,两组咳嗽程度评分、咳嗽频率评分、主症总评分均较同组治疗前显著降低(P<0.05);治疗后,治疗组主要症状评分显著低于对照组(P<0.05)。治疗后,两组口渴评分、咽痛评分、流涕评分、鼻塞评分、总评分均显著降低(P<0.05);治疗后,治疗组口渴评分显著低于对照组(P<0.05)。两组治疗1、2周中医证候总评分均较同组治疗前显著降低(P<0.05);治疗组治疗1、2周中医证候总评分显著低于对照组(P<0.05)。结论 止喘灵口服液治疗咳嗽变异性哮喘疗效显著,能够显著改善患儿的咳嗽症状,可应用于儿童咳嗽变异性哮喘风热袭肺证,该药药味精简,服用方便,安全性好。

Objective To investigate the therapeutic effect of Zhichuanling Oral Liquid in treatment of cough variant asthma in children (wind-heat attacking lung syndrome). Methods A total of 60 children with cough-variant asthma treated in the pediatric outpatient department of the Affiliated Hospital of Nanjing University of Chinese Medicine from November 2021 to December 2022 were selected and divided into control group (33 cases) and treatment group (27 cases) according to random number table method. Patients in the control group were po administered with Montelukast Sodium Oral Granules, children ≤ 2 years old and children < 5 years old were given Montelukast Sodium Granules with warm water, 4 mg/time, once a night. Children ≤ 5 years old Children < 14 years old swallowed Montelukast Sodium Chewable Tablets after chewing, 5 mg/time, once a night. Children in the treatment group were po administered with Zhichuanling Oral Liquid, 2 years≤ children < 3 years, 3 mL/time, 3 years old ≤ children < 9 years, 6 mL/time, ≥10 years old, 10 mL/time, 3 times daily. Both groups were treated for 2 weeks. The clinical efficacy of the two groups was observed, and the main symptom score, secondary symptom score and total TCM syndrome score of the two groups were compared. Results After treatment, the control rate of the treatment group was 63.0%, significantly higher than that of the control group (21.2%) (P < 0.05). The total effective rate was 96.3% in the treatment group and 90.9% in the control group. There was no significant difference between the two groups. After treatment, the score of cough severity, cough frequency and total score of main disease in two groups were significantly decreased compared with that before treatment (P < 0.05). After treatment, the main symptom score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, thirst score, throat pain score, runny nose score, nasal congestion score and total score were significantly decreased in two groups (P < 0.05). After treatment, the thirst score of treatment group was significantly lower than that of control group (P < 0.05). The total score of TCM syndromes in two groups after 1 and 2 weeks of treatment was significantly lower than that before treatment (P < 0.05). The total score of TCM syndrome in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Zhichuanling Oral Liquid has a remarkable effect in treatment of cough variant asthma in children (wind-heat attacking lung syndrome), and can significantly improve the cough symptoms of children, and can be applied to the wind-heat attack lung syndrome of children with cough variant asthma. The medicine has simple taste, convenient administration and good safety.