简化关节超声评分与类风湿关节炎患者关节炎症及骨破坏的相关性分析

Analysis on the Correlations of Simplified Joint Ultrasound Score with Joint Inflammation and Bone Destruction in Patients with Rheumatoid Arthritis

目的分析简化关节超声评分与类风湿关节炎(RA)患者关节炎症及骨破坏的相关性。方法72例RA患者根据DAS-28评分分为缓解期组、轻度活动期组和中重度活动期组,比较三组的ESR、CRP、RANKL水平及简化关节超声评分,分析ESR、CRP、RANKL水平与简化关节超声评分的相关性。结果中重度活动期组、轻度活动期组、缓解期组的ESR、CRP、RANKL水平及简化关节超声评分均依次降低(P<0.05)。Pearson直线相关性分析显示,ESR、CRP、RANKL水平与简化关节超声评分呈正相关(P<0.05)。结论简化关节超声评分随RA患者的病情进展而增高,可作为RA疾病活动度的评价指标。

Objective To analyze the correlations of simplified joint ultrasound score with joint inflammation and bone destruction in patients with rheumatoid arthritis(RA).Methods According to DAS-28 score,72 RA patients were divided into remission group,mild active group and moderate to severe active group.ESR,CRP,RANKL levels and simplified joint ultrasound score were compared among the three groups,and the correlations of ESR,CRP and RANKL levels with simplified joint ultrasound scores were analyzed.Results The levels of ESR,CRP and RANKL,and simplified joint ultrasound score in the moderate to severe active group,mild active group and remission group decreased in turn(P<0.05).Pearson linear correlation analysis showed that ESR,CRP and RANKL levels were positively correlated with simplified joint ultrasound score(P<0.05).Conclusions The simplified joint ultrasound score increases with the disease progression of RA patients,which can be used as an evaluation index of RA disease activity.