低剂量甲泼尼龙联合布地奈德对小儿重症支原体肺炎的影响

Impact of Low-Dose Methylprednisolone Combined with Budesonide on Severe Mycoplasma Pneumonia in Children

目的探讨低剂量甲泼尼龙联合布地奈德治疗小儿重症支原体肺炎的效果。方法选取我院2022年10月至2023年10月收治的98例重症支原体肺炎患儿,根据用药方案的不同分为两组。对照组48例给予布地奈德混悬液雾化吸入,观察组50例在对照组基础上给予低剂量甲泼尼龙琥珀酸钠治疗。比较两组的临床疗效、症状改善时间和不良反应。结果治疗后,观察组的总有效率为96.00%,高于对照组的79.17%(P<0.05)。观察组的退热时间、咳嗽缓解时间、肺部啰音消失时间、胸片恢复正常时间均短于对照组(P<0.05)。两组的药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论低剂量甲泼尼龙联合布地奈德治疗重症支原体肺炎的效果较好,可缓解患儿的症状体征,安全性高。

Objective To explore the effect of low-dose methylprednisolone combined with budesonide in the treatment of severe mycoplasma pneumonia in children.Methods 98 children with severe mycoplasma pneumonia admited to our hospital from October 2022 to October 2023 were selected and divided into two groups according to different medication regimens.48 cases in the control group were given budesonide suspension for atomization inhalation,and 50 cases in the observation group were given low-dose methylprednisolone sodium succinate on the basis of the control group.The clinical efficacy,symptom improvement time and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 96.00%,higher than 79.17%of the control group(P<0.05).The antipyretic time,cough relief time,lung rale disappearance time and chest X-ray recovery time of the observation group were shorter than those of the control group(P<0.05).No significant difference was found in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusions Low-dose methylprednisolone combined with budesonide in the treatment of severe mycoplasma pneumonia has good effect and high safety,and can relieve the symptoms and signs of children.