危重创伤患者输血治疗后血小板、纤维蛋白原与输血不良反应的相关性研究

Study on the Correlations of Platelet and Fibrinogen with Adverse Reactions of Blood Transfusion in Critically Ill Trauma Patients After Blood Transfusion Therapy

目的探讨危重创伤患者输血治疗后血小板、纤维蛋白原与输血不良反应的关系。方法84例危重创伤患者均给予输血治疗,比较输血前后的血小板和纤维蛋白原水平,分析血小板、纤维蛋白原与不良反应的相关性。结果输血后24~72h,血小板、纤维蛋白原水平逐渐升高。输血后,发生组的血小板和纤维蛋白原水平均低于未发生组(P<0.05),血小板、纤维蛋白原与不良反应的发生均呈负相关(r<0,P<0.05)。结论危重创伤患者输血治疗后血小板、纤维蛋白原与不良反应发生风险密切相关。

Objective To explore the correlations of platelet and fibrinogen with adverse reactions of blood transfusion in critically ill trauma patients after blood transfusion therapy.Methods 84 patients with critically ill trauma were treated with blood transfusion.The levels of platelets and fibrinogen before and after blood transfusion were compared,and the correlations of platelet and fibrinogen with the adverse reactions were analyzed.Results The levels of platelet and fibrinogen increased gradually at 24~72 h after blood transfusion.After blood transfusion,the platelet and fibrinogen levels in the occurrence group were lower than those in the non-occurrence group(P<0.05),and the platelet and fibrinogen levels were negatively correlated with the occurrence of adverse reactions(r<0,P<0.05).ConclusionSsThe platelet and fibrinogen of critically ill trauma patients after blood transfusion therapy are closely related to the risk of adverse reactions.