凝血指标、血小板参数与急性淋巴细胞白血病患儿出血事件发生的相关性分析

Analysis on the Correlation of Coagulation Indicators and Platelet Parameters with the Oecurrence of Bleeding Events in Children with Acute Lymphoblastic Leukemia

目的分析急性淋巴细胞白血病患儿的凝血指标、血小板参数与其出血事件发生的相关性。方法回顾性分析2021年1月至2022年12月期间我院收治的96例急性淋巴细胞白血病患儿的临床资料。依据是否发生出血事件,将患儿分为出血组和未出血组,比较两组的PT、D-D、PLT、MPV水平,分析PT、D-D、PLT、MPV与出血事件发生的相关性。结果出血组的PT、D-D水平均明显高于未出血组,PLT、MPV水平均明显低于未出血组(P<0.05)。Logistic回归分析显示,PT、D-D、PLT、MPV是急性淋巴细胞白血病患儿出血事件发生的影响因素(P<0.05)。结论急性淋巴细胞白血病患儿出血事件的发生与其凝血指标、血小板参数关系密切,临床应及时根据患儿凝血指标、血小板参数检测结果制定干预措施,以减少出血事件的发生。

Objective To analyze the correlation of coagulation indicators and platelet parameters with the occurrence of bleeding events in children with acute lymphoblastic leukemia.Methods The clinical data of 96 children with acute lymphoblastic leukemia admitted to our hospital from January 2021 to December 2022 were retrospectively analyzed.According to the occurrence of bleeding events,the children were divided into bleeding group and non-bleeding group.The levels of PT,D-D,PLT and MPV were compared between the two groups,and the correlations of PT,D-D,PLT and MPV with the occurrence of bleeding events were analyzed.Results The levels of PT and D-D in the bleeding group were significantly higher than those in the non-bleeding group,and the levels of PLT and MPV were significantly lower than those in the non-bleeding group(P<0.05).Logistic regression analysis showed that PT,D-D,PLT and MPV were the influencing factors for the occurrence of bleeding events in children with acute lymphoblastic leukemia(P<0.05).Conclusions The occurrence of bleeding events in children with acute lymphoblastic leukemia is closely related to their coagulation indicators and platelet parameters.Clinical intervention measures should be formulated in time according to the detection results of coagulation indicators and platelet parameters of children to reduce the occurrence of bleeding events.