烯丙雌醇联合黄体酮治疗先兆早产的效果

Effect of Allylestrenol Combined with Progesterone in the Treatment of Threatened Premature Labor

目的:探讨烯丙雌醇联合黄体酮在先兆早产患者应用效果。方法:选取2021年5月—2023年9月本院进行诊治的先兆早产患者82例作为研究对象,根据随机信封抽签原则把患者分为联合组41例与常规组41例。常规组给予黄体酮治疗,联合组在对照组治疗基础上给予烯丙雌醇治疗,比较两组腹痛缓解时间、腰酸缓解时间、出血停止时间、雌二醇含量、孕酮含量、不良反应发生率及人生结局。结果:联合组腹痛缓解时间、腰酸缓解时间、出血停止时间短于常规组(P<0.05);联合组治疗7 d后血清雌二醇、孕酮含量高于常规组(P<0.05);联合组治疗7 d期间不良反应发生率与常规组比较,差异无统计学意义(P>0.05);联合组的活产率为97.56%,高于常规组的80.49%(P<0.05)。结论:烯丙雌醇联合黄体酮可缩短先兆早产患者腹痛缓解时间、腰酸缓解时间、出血停止时间,也可促进血清雌二醇、孕酮的分泌,降低不良反应发生率,改善妊娠结局。

Objective:To explore the application effect of allylestrenol combined with progesterone in patients with threatened premature delivery.Methods:From May 2021 to September 2023,82 patients with threatened premature delivery who were treated in our hospital were selected as the research objects.According to the principle of random envelope drawing,the patients were divided into 41 patients in the combined group and 41 patients in the conventional group.The conventional group was treated with progesterone,and the combined group was treated with allylestrenol on the basis of the control group.The abdominal pain relief time,lumbar acid relief time,bleeding stop time,estradiol content,progesterone content,incidence of adverse reactions and life outcome were compared between the two groups.Results:The abdominal pain relief time,lumbar acid relief time and bleeding stop time in the combined group were shorter than those in the conventional group(P<0.05).After 7 days of treatment,the levels of serum estradiol and progesterone in the combined group were higher than those in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group and the conventional group during 7 days of treatment(P>0.05).The live birth rate of the combined group was 97.56%,which was higher than 80.49%of the conventional group(P<0.05).Conclusion:Allyl estradiol combined with progesterone can shorten the time of abdominal pain relief,lumbar acid relief and bleeding stop in patients with threatened preterm labor,and can also promote the secretion of serum estradiol and progesterone,reduce the incidence of adverse reactions and improve pregnancy outcomes.