黄体酮胶囊联合地屈孕酮治疗无排卵性功能失调性子宫出血的效果

Effect of Progesterone Capsule Combined with Dydrogesterone in the Treatment of Anovulatory Dysfunctional Uterine Bleeding

目的:探讨黄体酮胶囊联合地屈孕酮治疗无排卵性功能失调性子宫出血的疗效及对凝血指标的影响。方法:选择2020年6月—2022年8月医院妇科诊治的无排卵性功能失调性子宫出血患者86例作为研究对象,分为联合组43例与对照组43例。对照组给予黄体酮胶囊治疗,联合组给予黄体酮胶囊联合地屈孕酮治疗,比较两组治疗效果、凝血指标、子宫内膜厚度及不良反应发生情况。结果:联合组不良反应发生率与对照组比较,差异无统计学意义(P>0.05);联合组总有效率高于对照组(P<0.05);联合组子宫内膜厚度低于对照组(P<0.05);联合组血清雌二醇、孕酮含量高于对照组(P<0.05)。结论:黄体酮胶囊联合地屈孕酮治疗无排卵性功能失调性子宫出血的效果确切,可降低子宫内膜厚度,改善凝血功能状态,且不增加不良反应发生率,值得临床应用。

Objective:To investigate the efficacy of progesterone capsule combined with dydrogesterone in the treatment of anovulatory dysfunctional uterine bleeding and its effect on coagulation indexes.Methods:From June 2020 to August 2022,86 patients with anovulatory dysfunctional uterine bleeding diagnosed and treated in gynecology department of our hospital were selected as the research objects,and they were divided into combined group(43 patients)and control group(43 patients).The control group was treated with progesterone capsule,and the combined group was treated with progesterone capsule combined with dydrogesterone.The therapeutic effect,coagulation index,endometrial thickness and adverse reactions were compared between the two groups.Results:There was no significant difference in the incidence of adverse reactions between the combined group and the control group(P>0.05).The total effective rate of the combined group was higher than that of the control group(P<0.05).The endometrial thickness of the combined group was lower than that of the control group(P<0.05).The levels of serum estradiol and progesterone in the combined group were higher than those in the control group(P<0.05).Conclusion:Progesterone capsule combined with dydrogesterone is effective in the treatment of anovulatory dysfunctional uterine bleeding.It can reduce endometrial thickness and improve coagulation function without increasing the incidence of adverse reactions.It is worthy of clinical application.