中等剂量与高剂量阿托伐他汀治疗症状性大脑中动脉狭窄患者的效果比较

Comparison of the Effects of Medium-dose and High-dose Atorvastatin in the Treatment of Patients with Symptomatic Middle Cerebral Artery Stenosis

目的:比较中等剂量与高剂量阿托伐他汀治疗症状性大脑中动脉狭窄患者的效果。方法:回顾性分析我院2020年12月—2023年12月收治的80例症状性大脑中动脉狭窄患者,依据治疗方式将患者分为参照组(40例)、研究组(40例)。参照组应用中等剂量阿托伐他汀治疗,研究组应用高剂量阿托伐他汀治疗。比较两组血脂指标、预后良好率、动态脑血流自动调节(dCA)指标、卒中量表(NHISS)评分、mRS评分、不良反应。结果:治疗后,研究组HDL-C水平高于参照组,LDL-C、TC、TG水平均低于参照组(P<0.05);研究组预后良好率高于参照组(P<0.05);研究组增益低于参照组,相位差高于参照组(P<0.05);研究组NHISS评分、mRS评分均低于参照组(P<0.05);研究组不良反应发生率高于参照组,但差异无统计学意义(P>0.05)。结论:高剂量阿托伐他汀可有效改善症状性大脑中动脉狭窄患者dCA功能、血脂指标和神经功能,从而改善患者的预后,且不会导致不良反应发生率升高。

Objective:To compare the effects of medium-dose and high-dose atorvastatin in the treatment of patients with symptomatic middle cerebral artery stenosis.Methods:A retrospective analysis of 80 patients with symptomatic middle cerebral artery stenosis admitted to our hospital from December 2020 to December 2023 was conducted.The patients were divided into reference group(40 patients)and study group(40 patients)according to the treatment method.The reference group was treated with medium-dose atorvastatin,and the study group was treated with high-dose atorvastatin.The blood lipid indexes,good prognosis rate,dynamic cerebral autoregulation(dCA)index,stroke scale(NHISS)score,mRS score and adverse reactions were compared between the two groups.Results:After treatment,the level of HDL-C in the study group was higher than that in the reference group,and the levels of LDL-C,TC and TG were lower than those in the reference group(P<0.05).The good prognosis rate of the study group was higher than that of the reference group(P<0.05).The gain of the study group was lower than that of the reference group,and the phase difference was higher than that of the reference group(P<0.05).The BHISS score and mRS score of the study group were lower than those of the reference group(P<0.05).The incidence of adverse reactions in the study group was higher than that in the reference group,but the difference was not statistically significant(P>0.05).Conclusion:High-dose atorvastatin can effectively improve dCA function,blood lipid index and neurological function in patients with symptomatic middle cerebral artery stenosis,thereby improving the prognosis of patients,and will not lead to an increase in the incidence of adverse reactions.