舒血宁注射液联合脑苷肌肽治疗急性脑梗死的效果

Effect of Shuxuening Injection Combined with Cattle Encephalon Glycoside and Ignotin in the Treatment of Acute Cerebral Infarction

目的:观察舒血宁注射液联合脑苷肌肽治疗急性脑梗死患者的效果。方法:选取商丘市第五人民医院2021年12月—2022年12月收治的110例急性脑梗死患者,按照随机数字表法分为研究组(55例)与对照组(55例)。对照组采用脑苷肌肽治疗,研究组在对照组基础上联用舒血宁注射液,对比两组治疗总有效率、不良反应发生率、日常生活能力[肢体运动功能评分表(FMA)、巴塞尔指数评价表(BI)评分]、神经功能[神经功能缺损评估量表(NIHSS)、神经修复评价表(MRS)评分、S100β]、血小板指标(血小板黏附率、聚集率)、脑血流动力学[大脑前动脉血流速度(ACA)、基底动脉血流速度(BA)]。结果:研究组治疗总有效率、BI评分和FMA评分均高于对照组,且不良反应发生率、NIHSS评分、MRS评分、S100B蛋白水平、血小板聚集率及黏附率均低于对照组,同时ACA与BA快于对照组(P<0.05)。结论:舒血宁注射液联合脑苷肌肽在急性脑梗死患者早期康复治疗中的效果较好,能够有效促进神经系统与肢体功能的恢复,改善血小板聚合状态,加快脑部血液循环,进而降低致死致残率。

Objective:To observe the effect of Shuxuening injection combined with cattle encephalon glycoside and ignotin on patients with acute cerebral infarction.Methods:A total of 110 patients with acute cerebral infarction admitted to the Shangqiu Fifth People's Hospital from December 2021 to December 2022 were selected and divided into study group(55 patients)and control group(55 patients)according to the random number table method.The control group was treated with cattle encephalon glycoside and ignotin.The study group was treated with Shuxuening injection on the basis of the control group.The total effective rate,incidence of adverse reactions,daily living ability[limb motor function score table(FMA),Basel index evaluation table(BI)score I,neurological function[neurological deficit assessment scale(NIHSS),nerve repair evaluation table(MRS)score,S100β],platelet index(platelet adhesion rate,aggregation rate),cerebral hemodynamics[anterior cerebral artery blood flow velocity(ACA),basilar artery blood flow velocity(BA)]were compared between the two groups.Results:The total effective rate,BI and FMA scores in the study group were higher than those in the control group,and the incidence of adverse reactions,NIHSS score,MRS Score,S100βprotein level,platelet aggregation rate and adhesion rate were lower than those in the control group,while ACA and BA were faster than those in the control group(P<0.05).Conclusion:Shuxuening injection combined with cattle encephalon glycoside and ignotin has a good effect in the early rehabilitation treatment of patients with acute cerebral infarction.It can effectively promote the recovery of nervous system and limb function,improve the state of platelet aggregation,accelerate the blood circulation of the brain,and then reduce the mortality and disability rate.