蛋白质修饰组学-中药作用机制研究的新途径

Protein Modification Omics:A Novel Approach Investigating Mechanisms of Chinese Medicines

中医药作为我国宝贵的科学遗产与文化瑰宝,承载着中华民族数千年智慧的结晶,其深厚的医学理论和丰富的实践经验在我国卫生保健事业中占据着不可替代的核心地位。面对现代医学挑战与健康需求,深入探究中药作用机制显得尤为迫切和必要。蛋白质翻译后修饰(PTM),作为调控蛋白质功能复杂性和多样性的核心机制,是连接内外环境刺激与机体内在生理反应的关键桥梁。同时,不同类型PTM之间可相互作用形成复杂的调控网络,符合中药多成分、多靶点的作用特点。尽管蛋白质修饰组学作为探究PTM的有效工具,近些年已经被应用于一些中药作用机制研究,但总体而言,这一领域的研究在中药学领域尚处于初步发展阶段。为此,该文首先概述了PTM的基础理论和蛋白质修饰组学的基本研究流程,继而系统回顾了蛋白质修饰组学在中药作用机制研究领域的应用现状,并针对现存研究局限性进行了深入剖析。该文旨在探寻一种基于PTM视角解析中药作用机制的创新研究范式,为未来深化理解中药作用机理提供理论依据与实践指导。

Traditional Chinese medicine(TCM),as an invaluable scientific legacy and cultural patrimony of China,encapsulates the cumulative wisdom of millennia from the Chinese civilization.The deeply rooted medical theories and extensive empirical practices of TCM hold an indispensible central role within China's healthcare framework.Facing the challenges of modern medicine and health needs,it is particularly urgent to explore the mechanisms of Chinese medicines.Post-translational modification(PTM),as a core mechanism to regulate the complex and diverse protein functions,is a bridge between environmental stimuli and physiological responses.Different PTMs can interact with each other to form a complex regulatory network,which is in line with the multi-component and multi-target action of Chinese medicines.In recent years,protein modification omics has emerged as a powerful means to probe into PTMs,and studies have employed protein modification omics to investigate the mechanisms of Chinese medicines.However,the research in this field is still in the initial stage.This article summarizes the basic theory of PTM and the basic research process of protein modification omics,reviews the application status of protein modification omics in the research on the mechanisms of Chinese medicines,and analyzes the existing research limitations.This study aims to explore an innovative research paradigm for analyzing the mechanisms of Chinese medicines from the perspective of PTM and provide a theoretical basis and practical guidance for understanding the mechanisms of Chinese medicines in the future.