cGAS/STING信号通路调控缺血性脑卒中的机制及中药干预研究进展

Mechanism of CGAS-STING Signaling Pathway in Regulating Ischemic Stroke and Intervention of Traditional Chinese Medicine:A Review

缺血性脑卒中是临床常见的脑血管疾病,其发病率逐年上升。针对卒中的临床治疗目前以溶栓及静脉取栓等为主,这两种方式受时间限制较大,遗留病症较多,降低患者生存质量。研究发现,在卒中病理过程中存在多种通路机制,其中环鸟苷酸-腺苷酸合成酶(cGAS)/干扰素基因刺激因子(STING)通路就是其中一种。目前针对缺血性脑卒中的发生发展及中药干预卒中的机制国内外研究人员做了大量研究,结果发现中药调控cGAS/STING通路可以降低炎症反应和氧化应激,并减少神经细胞死亡,有效减轻卒中的脑损伤,对于改善卒中的症状及改善预后方面具有独特优势。该文主要归纳总结了近年来cGAS/STING通路调控卒中的机制及相关中药干预研究进展,以期为缺血性脑卒中的中医药特色治疗提供新思路。

Ischemic stroke is a common clinical cerebrovascular disease,and its incidence is increasing year by year.Current clinical treatments for stroke mainly include thrombolysis and intravenous thrombectomy,both of which are subject to significant time constraints and often result in residual symptoms,reducing the quality of life for patients.Research has found that there are multiple pathways and mechanisms in the pathological process of stroke,such as the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon gene(STING)pathway.Currently,researchers in China and abroad have conducted extensive studies on the occurrence and development of ischemic stroke,as well as the mechanism of traditional Chinese medicine(TCM)intervention for stroke.The results indicate that traditional Chinese medicine(TCM)can regulate the cGAS/STING pathway to reduce inflammation and oxidative stress,decrease neuronal cell death,and effectively alleviate brain damage from stroke,and it has unique advantages in improving symptoms and prognosis.This article summarized the recent research progress of the mechanism of cGAS/STING pathway regulation in stroke and related TCM intervention,so as to provide new ideas for the treatment of ischemic stroke with TCM characteristics.