沙丁胺醇联合盐酸氨溴索治疗慢性阻塞性肺疾病的疗效及对肺功能指标的影响

Efficacy of Salbutamol Combined with Ambroxol Hydrochloride in the Treatment of Chronic Obstructive Pulmonary Disease and its Effect on Pulmonary Function Indexes

目的研究沙丁胺醇联合盐酸氨溴索治疗慢性阻塞性肺疾病(COPD)的临床疗效及对患者肺功能指标的影响。方法以2020年6月-2023年6月横峰县妇幼保健院收治的62例COPD患者为研究对象,经随机数字表法分为对照组与观察组,各31例。两组均给予常规治疗,在此基础上,对照组应用沙丁胺醇治疗,观察组则采用沙丁胺醇联合盐酸氨溴索治疗,比较两组临床疗效、肺功能[用力肺活量(FVC)、1秒钟用力呼气容积(FEV_(1))、1秒率(FEV_(1)/FVC)]、症状缓解时间(咳嗽、咳痰、胸闷气短)、炎症指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)]、不良反应。结果观察组治疗总有效率为96.77%,高于对照组的83.87%(P<0.05);两组治疗后FVC、FEV_(1)、FEV_(1)/FVC指标高于治疗前,且观察组FVC、FEV_(1)、FEV_(1)/FVC高于对照组(P<0.05);观察组症状缓解时间(咳嗽、咳痰、呼吸困难)短于对照组(P<0.05);两组治疗后CRP、IL-6水平低于治疗前,且观察组CRP、IL-6水平低于对照组(P<0.05);观察组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论沙丁胺醇联合盐酸氨溴索治疗COPD的效果肯定,可改善患者肺功能,加速症状缓解,下调炎症指标,且具有较高用药安全性。

Objective To study the clinical efficacy of salbutamol combined with ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease(COPD)and its effect on pulmonary function indexes.Methods From June 2020 to June 2023,62 patients with COPD admitted to the Hengfeng County Maternal and Child Health Hospital were divided into control group and observation group by random number table method,with 31 patients in each group.Both groups were given conventional treatment.On this basis,the control group was treated with salbutamol,while the observation group was treated with salbutamol combined with ambroxol hydrochloride.The clinical efficacy,pulmonary function[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),one-second rate(FEV_(1)/FVC)],symptom relief time(cough,sputum,chest tightness and shortness of breath),inflammatory indexes[C-reactive protein(CRP),interleukin-6(IL-6)]and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.77%,which was higher than 83.87%in the control group(P<0.05).After treatment,the indexes of FVC,FEV_(1) and FEV_(1)/FVC in the two groups were higher than those before treatment,and the indexes in the observation group were higher than those in the control group(P<0.05).The symptoms relief time(cough,expectoration,dyspnea)in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of CRP and IL-6 in the two groups were lower than those before treatment,and the levels of CRP and IL-6 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Salbutamol combined with ambroxol hydrochloride is effective in the treatment of COPD,which can improve lung function,accelerate symptom relief,down-regulate inflammatory indicators,and has high drug safety.