逐瘀止痛汤治疗腰椎间盘突出症临床评价

Clinical Evaluation of Zhuyu Zhitong Decoction in the Treatment of Lumbar Disc Herniation

目的探讨逐瘀止痛汤治疗腰椎间盘突出症的临床疗效。方法选取医院2020年1月至2022年1月收治的腰椎间盘突出症患者100例,按随机数字表法分为对照组和观察组,各50例,两组患者均接受常规保守治疗(包括卧床休息、持续牵引及对症治疗),观察组患者加用逐瘀止痛汤。两组疗程均为1个月。结果观察组总有效率为96.00%,显著高于对照组的84.00%(P<0.05)。两组患者治疗后的中医证候积分、腰椎功能障碍指数、视觉模拟量表评分及前列腺素E2、P物质、多巴胺、白细胞介素6、白细胞介素1β、C反应蛋白、肿瘤坏死因子-α水平均显著降低,日本骨科协会评分均显著升高,且观察组上述指标改善程度均更显著(P<0.01)。观察组与对照组不良反应发生率相当(4.00%比8.00%,P>0.05)。结论逐瘀止痛汤治疗腰椎间盘突出症,能改善患者的腰椎功能,缓解疼痛,减轻炎性反应。

Objective To investigate the clinical efficacy of Zhuyu Zhitong Decoction in the treatment of lumbar disc herniation.Methods A total of 100 patients with lumbar disc herniation admitted to the hospital from January 2020 to January 2022 were selected and divided into the control group and the observation group by the random number table method,with 50 cases in each group.The patients in the two groups received routine conservative treatment(including rest on bed,continuous traction,symptomatic treatment),on this basis,the patients in the observation group received Zhuyu Zhitong Decoction.Both groups were treated for one month.Results The total effective rate in the observation group was 96.00%,which was significantly higher than 84.00%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome score,Oswestry disability index(ODI)score,Visual Analogue Scale(VAS)score,prostaglandin E2(PGE2),substance P(SP),dopamine(DA),interleukin-6(IL-6),interleukin-1β(IL-1β),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)levels in the two groups significantly decreased;the Japanese Orthopaedic Association(JOA)score in the two groups significantly increased;and the above indexes in the observation group were significantly better than those in the control group(P<0.01).The incidence of adverse reactions in the observation group was similar to that in the control group(4.00%vs.8.00%,P>0.05).Conclusion Zhuyu Zhitong Decoction can improve the lumbar vertebra function,relieve pain,and alleviate inflammatory reactions in patients with lumbar disc herniation.