基于倾向性评分匹配法的脑膜瘤切除术后感染危险因素分析

Risk Factors for Infection After Meningioma Resection Based on Propensity Score Matching

目的探讨脑膜瘤切除术术后感染危险因素。方法采用回顾性研究法,选取医院2020年1月至2021年12月行脑膜瘤切除术的患者288例,按是否出现术后感染分为感染组(91例)和未感染组(197例)。采用倾向性评分匹配法对两组患者进行1∶1匹配。采用Logistic回归模型分析评估脑膜瘤切除术后感染的独立危险因素。结果共成功匹配61对患者,Logistic回归模型分析结果显示,手术时长>4 h[OR=2.481,95%CI(1.126,5.466),P=0.024],预防用药选择不合理[OR=6.220,95%CI(1.231,31.423),P=0.027]和留置引流管[OR=2.634,95%CI(1.196,5.802),P=0.016]为脑膜瘤切除术术后感染的独立危险因素。结论临床药师应加强对医师预防用药合理使用宣教,对于手术时长>4 h、留置引流管的患者应提供个体化药学服务和用药监护。

Objective To investigate the risk factors for infection after meningioma resection.Methods A total of 288 patients who underwent meningioma resection in the hospital from January 2020 to December 2021 were selected and retrospectively analyzed.They were divided into the infected group(91 cases)and the uninfected group(197 cases)based on whether postoperative infection occurred.The two groups were matched at 1∶1 by the propensity score matching(PSM)method.The independent risk factors for infection after meningioma resection were evaluated by the Logistic regression model.Results A total of 61 pairs of patients were successfully matched.The Logistic regression analysis showed that the surgical duration>4 h[OR=2.481,95%CI(1.126,5.466),P=0.024],irrational selection of preventive medication[OR=6.220,95%CI(1.231,31.423),P=0.027]and indwelling drainage tube[OR=2.634,95%CI(1.196,5.802),P=0.016]were the independent risk factors for infection after meningioma resection.Conclusion Clinical pharmacists should strengthen the education on the rational use of preventive medication for physicians,and provide individualized pharmaceutical care and medication monitoring for patients with surgical duration>4 h and indwelling drainage tube.