加用盐酸利托君治疗早产胎膜早破患者的效果

Effect of Addition of Ritodrine Hydrochloride in the Treatment of Premature Rupture of Membranes

目的:观察早产胎膜早破患者应用盐酸利托君治疗方案所取得的临床效果。方法:选取2021年1月—2022年6月河南省上蔡县人民医院病发早产胎膜早破患者106例,将其随机分为对照组和观察组。对照组53例采用硫酸镁治疗方案,观察组53例在硫酸镁治疗基础上加用盐酸利托君治疗。结果:观察组患者临床效果总有效率、分娩结局相关值依据标准评估值对比对照组,差异有统计学意义(χ^(2)=8.4772、6.4459,P<0.05);观察组患者相关指标值依据标准评估对比对照组,差异有统计学意义(t=8.5575、10.9343、40.5157,P<0.05);在治疗工作实施后,观察组患者肿瘤坏死因子-α(TNF-α)指标、白介素-2(IL-2)指标值依据标准评估与对照组比较更低,差异有统计学意义(t=4.910、7.155,P<0.05);观察组患者焦虑指标、抑郁指标值依据标准评估与对照组比较更低,差异有统计学意义(t=10.773、10.540,P<0.05)。结论:针对病发早产胎膜早破患者,在硫酸镁治疗基础上联合盐酸利托君展开治疗,效果显著可缩短宫缩抑制时间、减少产后出血量、降低炎性指标水平、改善心理状态、提高足月分娩率以及胎儿存活率,降低早产风险。

Objective:To observe the clinical effect of ritodrine hydrochloride on premature rupture of membranes.Methods:106 patients with premature rupture of membranes(PROM)of premature delivery in the hospital were selected and randomly divided from January 2021 to June 2022,and they were randomly divided into control group and observation group.In the control group,53 patients were treated with magnesium sulfate alone,while in the observation group,53 patients were treated with ritodrine hydrochloride on the basis of magnesium sulfate.Results:There were statistically significant difference in the total effective rate of clinical effect,and the correlation value of childbirth outcome between observation group and control group(χ^(2)=8.4772,6.4459;P<0.05).There were statistically significant difference in the correlation index values according to the standard between obervation group and control group(t=8.5575,10.9343,40.5157;P<0.05).After the treatment,the TNF-αindex and IL-2 index values of the observation group were evaluated according to the standard,and compared with the control group,the results were lower(t=4.910,7.155;P<0.05).The anxiety and depression indexes of the observation group were evaluated according to the standard,and compared with the results of the control group,they were at a lower level(t=10.773,10.540;P<0.05).Conclusion:For patients with premature birth with premature rupture of membranes,magnesium sulfate therapy combined with ritodrine hydrochloride is effective,which can shorten the time of contraction inhibition,reduce postpartum blood loss,reduce inflammatory indicators,improve psychological state,increase the full-term delivery rate and fetal survival rate,and reduce the risk of premature birth.