氧化应激与铁死亡在糖尿病型阳痿中的相关性研究进展

Research progress on the correlation between oxidative stress and ferroptosis in diabetic impotence

糖尿病型阳痿(DMED)是临床上常见糖尿病相关的血管、内分泌及神经病变,DMED患者常表现为勃起困难、勃起所需时间延长、硬度差、性交时间短等症状。其病因机制复杂,常与氧化应激(OS)、炎症反应、神经及内分泌病变等众多因素密切相关,上述因素往往交叉反应,促进DMED病变进展。近年来相关研究表明,OS与铁死亡在DMED中起着关键型作用:OS可致糖尿病患者神经、内分泌功能异常,阴茎血管内皮的合成或生物利用度下降,海绵状内皮细胞功能障碍和平滑肌舒张功能减低,从而导致阴茎勃起障碍;而铁死亡经证实也与DMED密切相关,控制OS和铁死亡以改善糖尿病患者的勃起功能是合理有效的治疗路径,但铁死亡导致DMED的作用机制尚有待进一步研究。因此,文章综述了OS与铁死亡和DMED相关性的最新信息,为探索DMED发生机制、临床防治DMED提供有益参考,并为该领域未来的研究提供潜在方向。

Diabetes mellitus erectile dysfunction(DMED)is a common diabetic-related vascular,endocrine and neuropathy in clinical practice,and patients with DMED often present with symptoms such as difficulty in erection,prolonged erection time,poor hardness,and short sexual intercourse.The etiological mechanism is complex,and it is often closely related to many factors such as oxidative stress(OS),inflammatory response,and neurological and endocrine lesions,which often cross-react and promote the progression of DMED lesions.In recent years,relevant studies have shown that OS and ferroptosis play a key role in DMED:OS can cause neurological and Abnormal endocrine function,decreased synthesis or bioavailability of penile vascular endothelium,spongy endothelial cell dysfunction and decreased smooth muscle diastolic function,resulting in penile erectile dysfunction,and ferroptosis has also been confirmed to be closely related to DMED,controlling OS and ferroptosis to improve erectile function in diabetic patients is a reasonable and effective treatment pathway,but the mechanism of action of ferroptosis leading to DMED needs to be further studied.Therefore,this article reviews the latest information on the correlation between OS and ferroptosis and DMED,aiming to provide a useful reference for exploring the mechanism of DMED,clinical prevention and treatment of DMED,and providing potential directions for future research in this field.