miRNA在子痫前期中的研究进展

Research advances of miRNA in pre-eclampsia

子痫前期(PE)是一种产科疾病,可增加孕产妇出现脑出血、肺水肿、急性肾损伤、肝损伤、弥散性血管内凝血、子痫和胎盘早剥等风险,严重危及母儿生命安全。子痫前期的病理生理为多因素导致,研究表明胎盘功能障碍是导致子痫前期的主要原因。miRNA是一种单链非编码小分子RNA,研究证实子痫前期患者的miRNA表达失调,且miRNA在子痫前期中的功能和作用机制正逐渐被揭示。本综述总结了miRNA通过靶向下游靶蛋白在子痫前期中的主要作用,为miRNA在子痫前期预防和治疗中的作用提供证据。

Pre-eclampsia(PE)is an obstetric disorder that can seriously jeopardize the lives of both mother and child by increasing the risk of maternal cerebral hemorrhage,pulmonary edema,acute kidney injury,liver injury,disseminated intravascular coagulation,eclampsia,and placental abruption.The pathophysiology of pre-eclampsia is multifactorial.Studies have suggested that placental dysfunction is the main cause of pre-eclampsia.miRNA is a small,single-stranded,non-coding molecule RNA.Studies have confirmed that miRNA expression is dysregulated in patients with preeclampsia,and the function and mechanism of action of miRNAs in pre-eclampsia are gradually being revealed.This review summarizes the role of miRNAs in the development of PE by targeting downstream target proteins,providing evidence for the role of miRNAs in the prevention and treatment of pre-eclampsia.