天麻素注射液联合甲磺酸倍他司汀对急诊眩晕患者的症状缓解效果分析

Effect analysis of gastrodin injection combined with betahistine mesylate on symptom relief in emergency room patients with vertigo

目的分析天麻素注射液联合甲磺酸倍他司汀对急诊眩晕患者的症状缓解效果。方法115例急诊眩晕患者,采取双盲法分为对照组(57例)和观察组(58例)。对照组单纯采取甲磺酸倍他司汀治疗,观察组采取天麻素注射液联合甲磺酸倍他司汀治疗。比较两组患者临床症状消失时间、血液流变学指标(全血粘度、红细胞压积、红细胞聚集指数)、日常生活能力、生活质量、不良反应发生率、临床效果。结果观察组患者眩晕、恶心/呕吐、平衡功能异常消失时间分别为(3.83±1.74)、(5.36±1.78)、(5.49±1.76)d,均短于对照组的(5.98±1.89)、(8.91±2.08)、(9.25±1.87)d(P<0.05)。干预后,观察组患者全血粘度(4.26±0.89)mPa·s、红细胞压积(0.37±0.04)、红细胞聚集指数(3.76±0.32)均低于对照组的(5.17±0.82)mPa·s、(0.40±0.06)、(4.57±0.27)(P<0.05)。干预后,观察组患者日常生活活动能力量表(ADL)评分(77.59±4.27)分、Spitzer生活质量指数(7.53±1.39)分均高于对照组的(71.34±3.95)、(6.14±1.46)分(P<0.05)。观察组不良反应发生率6.90%低于对照组的21.05%(P<0.05)。观察组临床总有效率96.55%高于对照组的84.21%(P<0.05)。结论对眩晕患者急诊治疗过程中采取天麻素注射液联合甲磺酸倍他司汀干预方案,能尽快减轻临床症状,改善血液流变学,提高患者日常生活能力、生活质量及治疗效果,且不良反应发生率较低,值得推荐。

Objective To analyze the effect of gastrodin injection combined with betahistine mesylate on symptom relief in emergency patients with vertigo.Methods A total of 115 emergency room patients with vertigo were divided into a control group(57 cases)and an observation group(58 cases)by double-blind method.The control group was treated with betahistine mesylate alone,and the observation group was treated with gastrodin injection combined with betahistine mesylate.Patients in both groups were compared in terms of disappearance time of clinical symptoms,hemorheology indexes(whole blood viscosity,hematocrit,erythrocyte aggregation index),daily living ability,quality of life,incidence of adverse reactions,and clinical effect.Results The disappearance time of vertigo,nausea/vomiting and abnormal balance function in the observation group were(3.83±1.74),(5.36±1.78)and(5.49±1.76)d,which were shorter than(5.98±1.89),(8.91±2.08)and(9.25±1.87)d in the control group(P<0.05).After the intervention,the whole blood viscosity in the observation group was(4.26±0.89)mPa·s,the hematocrit was(0.37±0.04)and the erythrocyte aggregation index was(3.76±0.32),which were lower than(5.17±0.82)mPa·s,(0.40±0.06)and(4.57±0.27)in the control group(P<0.05).After the intervention,the scores of activities of daily living(ADL)and Spitzer's quality of life index were(77.59±4.27)and(7.53±1.39)points in the observation group,which were higher than(71.34±3.95)and(6.14±1.46)points in the control group(P<0.05).The incidence of adverse reactions was 6.90%in the observation group,which was lower than 21.05%in the control group(P<0.05).The total clinical effective rate of the observation group was 96.55%,which was higher than 84.21%of the control group(P<0.05).Conclusion In the emergency treatment of vertigo patients,gastrodin injection combined with betahistine mesylate can alleviate clinical symptoms,improve hemorheology,enhance patients'daily living ability,quality of life and therapeutic effect,and the incidence of adverse reactions is low,which is worthy of recommendation.