西曲瑞克联合阿司匹林预防早发型卵巢过度刺激综合征的疗效观察

Efficacy observation of cetrorelix combined with aspirin in preventing early-onset ovarian hyperstimulation syndrome

目的观察西曲瑞克联合阿司匹林预防早发型卵巢过度刺激综合征(OHSS)的疗效。方法回顾性收集2022年1月1日至7月1日于我院治疗的38例早发型OHSS患者资料,根据用药方案的不同分为对照组(19例)和干预组(19例)。取卵术后第1天,对照组患者给予阿司匹林肠溶片100 mg,口服至月经来潮;干预组患者给予注射用西曲瑞克0.25 mg,连续3 d皮下注射+阿司匹林肠溶片(用法用量同对照组)。观察并检测两组患者的首个黄体期、OHSS严重程度分级及取卵术后卵巢体积、腹水体积、血清雌二醇(E_(2))、白细胞计数(WBC)、红细胞比容(HCT)、中性粒细胞百分比(NEUT%)、D-二聚体(DD)、凝血酶原时间(PT)、纤维蛋白原(Fib)。结果干预组患者的首个黄体期显著短于对照组,中、重度患者比例显著低于对照组(P<0.05或P<0.01)。取卵术后,干预组患者的卵巢体积、腹水体积、血清E_(2)、WBC、NEUT%、HCT、DD、Fib总体低于对照组,PT显著高于对照组(P<0.05)。结论西曲瑞克联合阿司匹林预防早发型OHSS的疗效较单用阿司匹林更好。

OBJECTIVE To observe the efficacy of cetrorelix combined with aspirin in preventing early-onset ovarian hyperstimulation syndrome(OHSS).METHODS A retrospective analysis was conducted on clinical data from 38 early-onset OHSS patients,who received treatment in our hospital from January 1st to July 1st,2022.These patients were divided into intervention group(19 cases)and control group(19 cases)according to the therapy regimen.On the first day after oocyte retrieval surgery,the control group was given aspirin enteric-coated tablets 100 mg orally until menstruation began.The intervention group was given cetrorelix for injection 0.25 mg subcutaneously,for consecutive 3 days+aspirin enteric-coated tablets(same usage and dosage as the control group).The first luteal phase,the degree of OHSS,and the ovarian volume,ascites volume,serum estradiol(E_(2)),white blood cell count(WBC),hematocrit(HCT),neutrophil ratio(NEUT%),D-dimer(DD),prothrombin time(PT),fibrinogen(Fib)after oocyte retrieval surgery were observed and measured in 2 groups.RESULTS The first luteal phase was significantly shorter,and the proportions of median and severe OHSS cases were significantly lower in the intervention group compared to the control group(P<0.05 or P<0.01).After oocyte retrieval surgery,the intervention group showed significantly lower ovarian volume,ascites volume,serum E_(2),WBC,NEUT%,HCT,DD and Fib compared to the control group,but PT of intervention group was signiticantly higher than that of control group(P<0.05).CONCLUSIONS Cetrorelix combined with aspirin is more effective in preventing early-onset OHSS than aspirin alone.