艾司氯胺酮抗产后抑郁的临床应用

Clinical application of esketamine in the treatment of postpartum depression

剖宫产术后抑郁严重危害母婴身心健康,影响家庭和睦,加重社会经济负担,产妇抑郁的防治工作具有不言而喻的重要性。氯胺酮作为抗抑郁药在精神疾病治疗中备受关注,而新型的麻醉药艾司氯胺酮是氯胺酮的S-对映异构体,与N-甲基-D-天冬氨酸受体有更强大的亲和力,且不良反应较少。先前研究发现其在治疗难治性抑郁症及重度抑郁症中表现出不逊色于氯胺酮的抗抑郁效果,因此,在剖宫产术后抑郁的防治中有良好的应用前景。本文主要阐述艾司氯胺酮在产后抑郁的临床应用。

Depression after cesarean section seriously harms the physical and mental health of mother and baby,affects family harmony,and aggravates social and economic burden.The prevention and treatment of maternal depression is of self-evident importance.Ketamine,as an antidepressant,has attracted much attention in the treatment of mental illness.As the S-enantiomer of ketamine,esketamine,a new anesthetic,has stronger affinity with N-methyl-D-aspartic acid receptor and fewer adverse reactions.Previous studies showed that the antidepressant effect on treatment-refractory depression and major depressive disorder of esketamine is not inferior to that of ketam ine,indicating esketamine has a good application pros pect in the prevention and treatm ent of depression after cesarean section.This paper mainly expounds the clinical application of esketamine in the treatment of postpartum depression.