阿司匹林与蛛网膜下腔出血相关性的meta分析

Meta-analysis of correlation between aspirin and subarachnoid hemorrhage

目的评估阿司匹林与蛛网膜下腔出血(SAH)的相关性。方法计算机检索PubMed、中国知网等国内外数据库,检索时限为建库至2023年4月,研究人员对纳入文献的结果进行综合评价。结果最终纳入12篇文献。总的meta分析结果显示,阿司匹林可显著降低SAH风险(OR=0.61,95%CI:0.42~0.88,P=0.007)。亚组分析:在一般人群中,阿司匹林对SAH并无显著影响(OR=1.00,95%CI:0.72~1.40,P=0.98);而在颅内动脉瘤患者中,阿司匹林具有保护作用(OR=0.32,95%CI:0.20~0.53,P<0.00001)。结论阿司匹林可降低颅内动脉瘤患者的SAH风险,而对一般人群无保护作用。

Objective To evaluate the correlation between aspirin and subarachnoid hemorrhage(SAH).Methods The domestic and foreign databases,such as PubMed and CNKI,were retrieved by computer,and the retrieval time was from the establishment of the database to April 2023.The researchers comprehensively evaluated the results of the included documents.Results Finally,12 articles were included.Meta-analysis showed that aspirin could significantly reduce the risk of SAH(OR=0.61,95%CI:0.42-0.88,P=0.007).Subgroup analysis showed that in the general population,aspirin had no statistically significant impact on SAH(OR=1.00,95%CI:0.72-1.40,P=0.98).However,in patients with intracranial aneurysms,aspirin had a protective effect(OR=0.32,95%CI:0.20-0.53,P<0.00001).Conclusion Aspirin can reduce the risk of SAH in patients with intracranial aneurysms,but it has no protective effect on the general population.