抗NMDAR抗体自身免疫性脑炎1例

A case of autoimmune encephalitis with anti-NMDAR antibody

自身免疫性脑炎(AE)是指由自身免疫所介导的脑炎,涉及多种自身免疫性抗体,临床表现也不尽相同,在过去多为排他性诊断。多数AE患者查头颅磁共振成像(MRI)可见异常信号,易被误诊为颅脑肿瘤。部分AE可能合并相关肿瘤,这种被称为副肿瘤性AE,在临床上存在漏诊可能。随着国内外多项相关研究的开展以及各种相关文章的发表,临床工作者对AE的认识更为完善。本案例较为典型,可以帮助临床工作者对AE进一步认识和学习。

Autoimmune encephalitis(AE)refers to encephalitis mediated by autoimmunity.There are diverse kinds of autoimmune antibodies involved,and their clinical manifestations are also different.In the past,AE was mostly diagnosed exclusively.Most patients with AE have abnorm al signals on magnetic resonance imaging(MRI),which are easily misdiagnosed as brain tumors.Some AE may be complicated by related tumors,which is called paraneoplastic AE,so there is the possibility of missed diagnosis in clinic.With the development of multiple related research both domestically and internationally,and the publication of various related literatures,clinical workers have a more comprehensive understanding of AE as a disease.This case is relatively typical and can help clinical workers to further understand and learn about AE.