艾滋病患者血清miR-210-5p、miR-23a-3p和miR-296-5p的检测意义分析

Detection significance analysis of microRNA-210-5p,microRNA-23a-3p and microRNA-296-5p in serum of acquired immunodeficiency syndrome patients

目的研究艾滋病(AIDS)患者血清微小RNA(miR)-210-5p、miR-23a-3p及miR-296-5p的检测意义。方法选取2020年5月至2023年5月鹤壁市传染病医院收治的100例AIDS患者作为研究对象,设为AIDS组。另选取同期健康志愿者100例设为参考组。比较两组血清miR-210-5p、miR-23a-3p及miR-296-5p水平。根据AIDS患者预后将AIDS组分为预后不良组、预后良好组,比较两组血清miR-210-5p、miR-23a-3p、miR-296-5p水平。采用多因素Logistic回归分析AIDS患者预后不良的影响因素。结果AIDS组血清miR-210-5p、miR-23a-3p水平均高于参考组,miR-296-5p水平低于参考组,差异具有统计学意义(P<0.05)。预后不良组血清miR-210-5p、miR-23a-3p水平均高于预后良好组,miR-296-5p水平低于预后良好组,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,miR-210-5p、miR-23a-3p水平升高及miR-296-5p水平降低均是AIDS患者预后不良的危险因素(P<0.05)。结论AIDS患者血清miR-210-5p、miR-23a-3p水平异常升高,miR-296-5p水平异常降低,其均对AIDS患者的预后具有一定的评估作用。

Objective To investigate the detection significance of microRNA(miR)-210-5p,miR-23a-3p and miR-296-5p in the serum of acquired immunodeficiency syndrome(AIDS)patients.Methods A total of 100 cases of AIDS patients treated in Hebi Infectious Diseases Hospital from May 2020 to May 2023 were selected as the study objects and set as the AIDS group.Another 100 healthy volunteers were selected as the reference group.Serum levels of miR-210-5p,miR-23a-3p and miR-296-5p were compared between the AIDS group and reference group.According to the prognosis of AIDS patients,they were divided into poor prognosis group and good prognosis group.Serum levels of miR-210-5p,miR-23a-3p and miR-296-5p were compared between the poor prognosis group and good prognosis group.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in AIDS patients.Results The levels of serum miR-210-5p and miR-23a-3p in AIDS group were higher than that in reference group,and the levels of miR-296-5p were lower than that in reference group,with statistical significances(P<0.05).The levels of miR-210-5p and miR-23a-3p in the poor prognosis group were higher than that in the good prognosis group,and the levels of miR-296-5p were lower than that in the good prognosis group,with statistical significances(P<0.05).Multivariate Logistic regression analysis showed that increased levels of miR-210-5p and miR-23a-3p and decreased levels of miR-296-5p were risk factors for poor prognosis in AIDS patients(P<0.05).Conclusions The serum levels of miR-210-5p and miR-23a-3p are abnormally increased and the levels of miR-296-5p are abnormally decreased in AIDS patients,all of which have a certain role in evaluating the prognosis of AIDS patients.