RMUS术治疗混合性尿失禁中尿急症、急迫性尿失禁症状的疗效观察

Mixed urinary incontinence:will urgency and urge urinary incontinence symptoms resolve after RMUS?

目的探索经阴道经耻骨后无张力尿道中段吊带(RMUS)术治疗混合性尿失禁(MUI)中尿急症、急迫性尿失禁(UUI)症状的疗效。方法回顾性分析2018年1月—2020年12月上海交通大学医学院附属仁济医院采用RMUS术治疗的44例女性MUI患者的临床资料。44例患者术前压力诱发试验、尿道抬举试验均为阳性。27例患者术前完成国际尿失禁咨询委员会女性下尿路症状长问卷(ICIQ-FLUTS-LF)调查,44例患者接受尿动力学(UDS)检查,其中9例(20.5%)出现逼尿肌过度活动(DO)。所有患者RMUS术中均通过解剖定位调整吊带张力。分析手术治疗效果和患者尿失禁改善情况。结果本研究44例患者平均年龄(58.59±9.08)岁,身体质量指数24.71±2.77。术后2年完成电话随访40例,主观治愈率为85.0%(34/40)。在27例完成ICIQ-FLUTS-LF问卷的患者中,手术前后漏尿发生率[100%(27/27)vs.18.5%(5/27)]、压力性尿失禁(SUI)发生率[100%(27/27)vs.18.5%(5/27)]、UUI发生率[70.4%(19/27)vs.29.6%(8/27)]差异均具有统计学意义(P<0.05);患者手术前后夜尿(≥1次)、尿急症、尿痛、排尿踌躇、排尿费力、排尿中断、遗尿发生率差异无统计学意义(P>0.05)。根据术前UDS检查结果进行的患者亚组分析显示,术后2年DO组和无DO组患者的主观治愈率差异有统计学意义[(55.6%(5/9)vs.93.5%(29/31),P<0.05],且两组患者术后SUI发生率[66.7%(4/6)vs.4.8%(1/21)]和UUI发生率[66.7%(4/6)vs.19.0%(4/21)]差异均有统计学意义(P<0.05),但尿急症发生率[66.7%(4/6)vs.33.3%(7/21)]差异无统计学意义(P>0.05)。结论采用RMUS术治疗压力诱发试验和尿道抬举试验阳性的MUI患者有效,术后可改善患者的SUI和UUI症状,但对于尿急症无明显改善。此外,DO组患者术后2年的主观治愈率劣于无DO组。

Objective To explore the efficacy of retropubic midurethral synthetic sling(RMUS)in relieving urgency and urge urinary incontinence(UUI)symptoms in patients with mixed urinary incontinence(MUI).Methods Clinical data of 44 female MUI patients treated with RMUS during Jan.2018 and Dec.2020 in Shanghai Renji Hospital were retrospectively analyzed.All patients had positive results in stress test and Marshall-Marchetti test before operation,and 27 of them completed ICIQ-FLUTS-LF questionnaire.Urodynamic(UDS)tests suggested that 9 patients(20.5%)presented detrusor overactivity(DO).During RMUS procedure,the tension of the sling was adjusted based on the anatomical landmarks.The postoperative efficacy and improvement of urinary incontinence were analyzed.Results The patients aged(58.59±9.08)years,with a body mass index of 24.71±2.77.Among the 40 patients who completed telephone interview 2 years after surgery,the subjective cure rate was 85.0%(34/40).Among the 27 patients with records of questionnaires before and after surgery,there were significant differences in the incidence of urine leakage[100%(27/27)vs.18.5%(5/27)],stress urinary incontinence(SUI)[100%(27/27)vs.18.5%(5/27)]and UUI[70.4%(19/27)vs.29.6%(8/27)](P<0.05).However,no statistical differences were found regarding nocturia voiding episode(≥1 times),urgency,dysuria,hesitancy,strain to void,intermittent stream and enuresis(P>0.05).Based on preoperative UDS test,there were significant differences regarding the subjective cure rate in patients with or without preoperative DO[55.6%(5/9)vs.93.5%(29/31)],incidence of SUI[66.7%(4/6)vs.4.8%(1/21)],and UUI[66.7%(4/6)vs.19.0%(4/21)](P<0.05),while there was no statistical difference regarding urgency[66.7%(4/6)vs.33.3%(7/21)](P>0.05).Conclusion RMUS is effective in treating MUI patients with positive stress test and Marshall-Marchetti test results,which can relieve SUI and UUI symptoms,but has no effects on urgency symptoms.DO on preoperative urodynamics results in poorer subjective outcomes.